Show threadVictoria Stuart ๐Ÿ‡จ๐Ÿ‡ฆ ๐Ÿณ๏ธโ€โšง๏ธSep 9, 2023

Addendum 1

CAR-T-cell therapy w/o side effects
https://www.sciencedaily.com/releases/2023/09/230907162605.htm

* pts exp. incredible recoveries after CAR-T-cell therapy
* also endure incredibly strong side effects
* partly due to lymphodepleting chemotherapy before CAR-T-cells reinfused
* Can CAR-T-cell therapy be performed w/o lymphodepleting chemotherapy?

Efficient T cell adoptive transfer in lymphoreplete hosts mediated by transient activation of Stat5 signaling
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(23)00395-7

#cancer #Tcells #immunotherapy #Stat5

CAR-T-cell therapy without side effects? Researchers show results in preclinical models

Some patients have experienced incredible recoveries after CAR-T-cell therapy. But they've also endured incredibly strong and scary side effects, in part because of the lymphodepleting chemotherapy that is performed before the CAR-T-cells are reinfused. What if CAR-T-cell therapy could be performed without lymphodepleting chemotherapy?

ScienceDaily
Show threadGunning GroupDec 23, 2022
Our recent work has focused on the development of small-molecule inhibitors for #HDAC enzymes as well as the "undruggable" transcription factors #STAT3 and #STAT5 as potential treatments for hematological malignancies and other cancers.
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.0c01922
https://www.nature.com/articles/s41467-019-10422-7
https://www.nature.com/articles/s41375-017-0005-9