Ron Beavis ❌UCP3:p is also a mitochondrial inner membrane transport molecule, but it is most frequently observed in striated muscle. The idea that this sequence is used to "uncouple" ATP production to produce heat has been challenged & alternate functions proposed, e.g. Di Marchi, 2011 (https://pubmed.ncbi.nlm.nih.gov/21775425/)
Human & mouse uncoupling protein 3 (#UCP3:p | #SLC25A9:p)―GPMDB tissue tabbulations #proteomics #uncoupling
Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production - PubMed
The uncoupling proteins UCP2 and UCP3 have been postulated to catalyze Ca(2+) entry across the inner membrane of mitochondria, but this proposal is disputed, and other, unrelated proteins have since been identified as the mitochondrial Ca(2+) uniporter. To clarify the role of UCPs in mitochondrial C …