Mastodawn

When ever I see a paper claiming to do proteome-wide this, that & the other, genuinely all I want them to do is to pick a couple of interesting examples & do them so well that they can be held up as a standard of good scientific practice.

Ron Beavis ❌3h ago

Az 1d ago

i love how space travel went from Star Trek: The Next Generation to Deep Space 9 in the space of one (1) lunar mission.

Apollo program: boldly going where nobody has been before, everyone is a decorated pilot putting their lives on the line in the most advanced tech.

Artemis II: shitters broken, "I have two versions of Outlook and neither of them are working".

Ron Beavis ❌3h ago

#proteomics_101 List the 3 most important practical problems associated with analyzing human proteomics data for single amino acid variants, other than trivial computational issues.

Ron Beavis ❌4h ago

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Dave Tabb 5h ago

I shoot mass spectrometry and bioinformatics training videos for my YouTube channel, found here:
https://www.youtube.com/@DavidTabb

David Tabb

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

YouTube

Ron Beavis ❌5h ago

David Chisnall (*Now with 50% more sarcasm!*)7h ago

The Anthropic code leak is showing that contrary to claims made by AI sceptics, it is possible for humans to understand the output of LLM code generators on large and complex codebases. This has shown limitations in conventional office chair design and may require some new health and safety rules instituted in places that allow LLM use, due to the large number of reports of people falling out of their chairs laughing.

Ron Beavis ❌1d ago

diana 🏳️‍⚧️🦋🌱1d ago

The year 2026 in one animation

#year2026

Ron Beavis ❌1d ago

I must have missed this policy plank during the most recent election ...
https://www.youtube.com/watch?v=dV5cQ9tNkm8

Trump says federal government can't pay for daycare because money is needed for military

YouTube

Ron Beavis ❌1d ago

Tom Czarniecki 1d ago

So much this. If the aim is to ship stuff, then the bots can already outship us. If the aim is to grow a next generation of thinkers then the bots don't help.

"The real threat is a slow, comfortable drift toward not understanding what you're doing. Not a dramatic collapse. Not Skynet. Just a generation of researchers who can produce results but can't produce understanding. Who know what buttons to press but not why those buttons exist. Who can get a paper through peer review but can't sit in a room with a colleague and explain, from the ground up, why the third term in their expansion has the sign that it does."

https://ergosphere.blog/posts/the-machines-are-fine/

The machines are fine. I'm worried about us.

On AI agents, grunt work, and the part of science that isn't replaceable.

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Ron Beavis ❌1d ago

Extra points will be given if you can provide an illustrated explanation of the purpose and function of a "scramblase".

Ron Beavis ❌1d ago

#proteomics_101 Yeast IST2:p is an ER/plasma membrane scramblase. It has 8 transmembrane domains (grey) and an S/T-pIDR cward of its last TM. It does not have a ER signal peptide, so it is synthesized in the cytoplasm. Using diagrams, show how it is mechanically inserted into the ER membrane.