Nuclear localization of
#TDP43 is crucial for its function during
#RNAprocessing &
#neurodegeneration. @AyalaLab1 &co show that
#RNAbinding & macromolecular assembly, including via
#LLPS, play a central role in TDP-43 nuclear retention
#PLOSBiology https://plos.io/3v372fT
RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention
TDP-43 nuclear localization is crucial for its function during RNA processing and pathogenesis of neurodegenerative disorders. This manuscript demonstrates that RNA binding and macromolecular assembly, through multivalent interactions and liquid-liquid phase separation, play a central role in TDP-43 nuclear retention.
Wow, from the abstract this paper from Christine Mayr lab looks super interesting!
"mRNA interactions with disordered regions control protein activity"
#mRNA #translation #mRNALocalization #ProteinStructure #RNAbinding
https://www.biorxiv.org/content/10.1101/2023.02.18.529068v1?med=mas
This Primer explores a
#PLOSBiology study which shows that 2 known congenital
#hydrocephalus Trim71 mutations lead to distinct ectopic
#RNAbinding that influences
#neurogenesis in vitro & may contribute to pathology. Primer:
https://plos.io/3xd98Y4 Paper:
https://plos.io/3IbzKz4
Gain-of-function mutations in Trim71 linked to congenital hydrocephalus
Mutations in the RNA-binding domain of Trim71 can cause congenital hydrocephalus (CH). This Primer explores a recent study in PLOS Biology which shows that two known CH-associated Trim71 mutations lead to distinct ectopic RNA binding; these gain-of-function mechanisms influence neurogenesis in vitro and may contribute to CH pathology.
This Primer explores a
#PLOSBiology study which shows that 2 known congenital
#hydrocephalus Trim71 mutations lead to distinct ectopic
#RNAbinding that influences
#neurogenesis in vitro & may contribute to pathology. Primer:
https://plos.io/3xd98Y4 Paper:
https://plos.io/3IbzKz4Gain-of-function mutations in Trim71 linked to congenital hydrocephalus
Mutations in the RNA-binding domain of Trim71 can cause congenital hydrocephalus (CH). This Primer explores a recent study in PLOS Biology which shows that two known CH-associated Trim71 mutations lead to distinct ectopic RNA binding; these gain-of-function mechanisms influence neurogenesis in vitro and may contribute to CH pathology.
This Primer explores a
#PLOSBiology study which shows that 2 known congenital
#hydrocephalus Trim71 mutations lead to distinct ectopic
#RNAbinding that influences
#neurogenesis in vitro & may contribute to pathology. Primer:
https://plos.io/3xd98Y4 Paper:
https://plos.io/3IbzKz4Gain-of-function mutations in Trim71 linked to congenital hydrocephalus
Mutations in the RNA-binding domain of Trim71 can cause congenital hydrocephalus (CH). This Primer explores a recent study in PLOS Biology which shows that two known CH-associated Trim71 mutations lead to distinct ectopic RNA binding; these gain-of-function mechanisms influence neurogenesis in vitro and may contribute to CH pathology.
PLOS Biology
Gal Haimovich 😷🔬☣🏳️🌈🏳️⚧