Nuclear localization of
#TDP43 is crucial for its function during
#RNAprocessing &
#neurodegeneration. @AyalaLab1 &co show that
#RNAbinding & macromolecular assembly, including via
#LLPS, play a central role in TDP-43 nuclear retention
#PLOSBiology https://plos.io/3v372fT
RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention
TDP-43 nuclear localization is crucial for its function during RNA processing and pathogenesis of neurodegenerative disorders. This manuscript demonstrates that RNA binding and macromolecular assembly, through multivalent interactions and liquid-liquid phase separation, play a central role in TDP-43 nuclear retention.
Dorothee Dormann receives an ERC Consolidator Grant to support her research into neurodegenerative diseases
Dorothee Dormann receives an ERC Consolidator Grant to support her research into neurodegenerative diseases
TDP-43 represses cryptic exon splicing in
#UNC13A, a risk factor for
#AmyotrophicLateralSclerosis (
#ALS) &
#FrontotemporalDementia (
#FTD). While
#TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab
#PLOSBiology https://plos.io/3LB8ITH
TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A
This study shows that TDP-43 is the most important repressor of cryptic exon splicing in UNC13A, a risk factor for amyotrophic lateral sclerosis and frontotemporal dementia. While TDP-43 is the main repressor of UNC13A cryptic exon inclusion, other hnRNPs contribute to its regulation and may potentially act as disease modifiers.
TDP-43 represses cryptic exon splicing in
#UNC13A, a risk factor for
#AmyotrophicLateralSclerosis (
#ALS) &
#FrontotemporalDementia (
#FTD). While
#TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab
#PLOSBiology https://plos.io/3LB8ITHTDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A
This study shows that TDP-43 is the most important repressor of cryptic exon splicing in UNC13A, a risk factor for amyotrophic lateral sclerosis and frontotemporal dementia. While TDP-43 is the main repressor of UNC13A cryptic exon inclusion, other hnRNPs contribute to its regulation and may potentially act as disease modifiers.
TDP-43 represses cryptic exon splicing in
#UNC13A, a risk factor for
#AmyotrophicLateralSclerosis (
#ALS) &
#FrontotemporalDementia (
#FTD). While
#TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab
#PLOSBiology https://plos.io/3LB8ITHTDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A
This study shows that TDP-43 is the most important repressor of cryptic exon splicing in UNC13A, a risk factor for amyotrophic lateral sclerosis and frontotemporal dementia. While TDP-43 is the main repressor of UNC13A cryptic exon inclusion, other hnRNPs contribute to its regulation and may potentially act as disease modifiers.
#she believed she could, so #she did. Dr. Virginia Man-Lee @PennMedicine #breakthroughprize #TDP43
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RT @PennMedicine
Dr. Virginia Man-Yee Lee is one of the world’s most renowned researchers. But as a woman #STEM, Dr. Lee had to work harder to prove her value throughout her career.
Read her inspiring story and advice for rising female scientists:
#womenshistorymonth
http://spr.ly/60193xoHc
https://twitter.com/PennMedicine/status/1631774199277658114
She believed she could, so she did: How world-renowned scientist Virginia Lee navigated her prominent career as a woman - Penn Memory Center
Dr. Virginia Man-Yee Lee is one of the world’s most recognized and decorated researchers. This is her story.
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