Vladimir Savić😜
"It's not gambling if you're insider trading!" #q #PredictionMarkets
Rxiv cytoskeleton📰 "Ising Models of Cooperativity in Muscle Contraction"
https://arxiv.org/abs/2603.03866
#Cond-Mat.Stat-Mech #Cond-Mat.Mes-Hall #Q-Bio.Mn #Actin
https://arxiv.org/abs/2603.03866
#Cond-Mat.Stat-Mech #Cond-Mat.Mes-Hall #Q-Bio.Mn #Actin
Ising Models of Cooperativity in Muscle Contraction
Regulation of contraction in striated muscle is controlled by a dual mechanism involving both thin filaments containing actin and thick filaments containing myosin. The thin filament is activated by calcium ions binding to troponin, leading to tropomyosin azimuthal displacement which allows the activation of a regulatory unit (composed of one troponin, one tropomyosin and seven actin monomers) that exposes the actin sites for interaction with the myosin motors. Motor attachment to actin contributes to spreading activation within and beyond a regulatory unit along the thin filament through a cooperative mechanism. We introduce a one-dimensional Ising model to elucidate the mechanism of cooperativity in thin filament activation in relation to the force generated by the attached myosin motor. The model characterizes thin filament activation and cooperativity using only two parameters: one related to calcium concentration and the other to the force exerted by the attached myosin motor, which is modulated by temperature. At any force, the model is able to determine the extent of actin-myosin interactions on a correlation length ranging from two to seven actin monomers in addition to the seven actin monomers of the regulatory unit. Our theoretical predictions are successfully tested on experimental data, and our tests also include the condition of hindered filament activation by the use of the specific drug Omecamtiv Mecarbil (OM). According to our model, the effect of OM results in an anti-cooperativity mechanism accounting for the experimental data.
Rxiv mechanobio📰 "Quantifying the Spatiotemporal Dynamics of Engineered Cardiac Microbundles"
https://arxiv.org/abs/2604.07576 #Q-Bio.Qm #Dynamics #Stat.Ap #Cell
https://arxiv.org/abs/2604.07576 #Q-Bio.Qm #Dynamics #Stat.Ap #Cell
Quantifying the Spatiotemporal Dynamics of Engineered Cardiac Microbundles
Brightfield time-lapse imaging is widely used in cardiac tissue engineering, yet the absence of standardized, interpretable analytical frameworks limits reproducibility and cross-platform comparison. We present an open, scalable computational pipeline for quantifying spatiotemporal contractile dynamics in microscopy videos of human induced pluripotent stem cell-derived cardiac microbundles. Building on our open-source tools "MicroBundleCompute" and "MicroBundlePillarTrack," we define a suite of 16 interpretable structural, functional, and spatiotemporal metrics that capture tissue deformation, synchrony, and heterogeneity. The framework integrates full-field displacement tracking, strain reconstruction, spatial registration, dimensionality reduction, and topology-based vector-field analysis within a unified workflow. Applied to a dataset of 670 cardiac microbundles spanning 20 experimental conditions, the pipeline reveals continuous variation in contractile phenotypes rather than discrete condition-specific clustering, with intra-condition variability often exceeding inter-condition differences. Redundancy analysis identifies a reduced core set of 10 metrics that retain most informational content while minimizing multicollinearity. Analysis of denoised displacement fields shows that contraction is dominated by a global isotropic mode, with localized saddle-type deformation patterns present in approximately half of the samples. All software and workflows are released openly to enable reproducible, scalable analysis of dynamic tissue mechanics.
📰 "Ising Models of Cooperativity in Muscle Contraction"
https://arxiv.org/abs/2603.03866 #Cond-Mat.Stat-Mech #Cond-Mat.Mes-Hall #Q-Bio.Mn #Force #Actin
https://arxiv.org/abs/2603.03866 #Cond-Mat.Stat-Mech #Cond-Mat.Mes-Hall #Q-Bio.Mn #Force #Actin
Ising Models of Cooperativity in Muscle Contraction
Regulation of contraction in striated muscle is controlled by a dual mechanism involving both thin filaments containing actin and thick filaments containing myosin. The thin filament is activated by calcium ions binding to troponin, leading to tropomyosin azimuthal displacement which allows the activation of a regulatory unit (composed of one troponin, one tropomyosin and seven actin monomers) that exposes the actin sites for interaction with the myosin motors. Motor attachment to actin contributes to spreading activation within and beyond a regulatory unit along the thin filament through a cooperative mechanism. We introduce a one-dimensional Ising model to elucidate the mechanism of cooperativity in thin filament activation in relation to the force generated by the attached myosin motor. The model characterizes thin filament activation and cooperativity using only two parameters: one related to calcium concentration and the other to the force exerted by the attached myosin motor, which is modulated by temperature. At any force, the model is able to determine the extent of actin-myosin interactions on a correlation length ranging from two to seven actin monomers in addition to the seven actin monomers of the regulatory unit. Our theoretical predictions are successfully tested on experimental data, and our tests also include the condition of hindered filament activation by the use of the specific drug Omecamtiv Mecarbil (OM). According to our model, the effect of OM results in an anti-cooperativity mechanism accounting for the experimental data.
Japan Pop Newshttps://www.wacoca.com/news/2810201/ レバノン、イスラエルとの協議に向け一時停戦提唱 ヒズボラは直接交渉拒否 | ロイター ##war #AE #AMERS #Asia #ASXPAC #BH #BISV #BMAT #BreakingNews #CWP #Def #DEST:NOJPTPM #DEST:NOJPWDM #DEST:NOJPZTM #dip #EMEA #EMEAE #EMRG #ENER #ENFF #eng #Fin #FINS #Gen #IL #INVBIS #IQ #IR #Israel #JFOR #JLN #KW #LB #MEAST #MEASTE #MINE #MTAL #NAMER #NEWS1 #NUCL #OILG #om #PK #POL #Q&A #SA #SASIA #SECUR #SWASIA #TGLF #TRN #US #Ye #イスラエル #速報ニュース
YAYAFAイスラエル首相、レバノンとの和平交渉開始指示 米で来週開催と報道 | ロイター https://www.yayafa.com/2777322/ ##LB #Ae #AMERS #Asia #ASXPAC #BH #CWP #Def #DEST:NOJPTPM #DEST:NOJPWDM #DEST:NOJPZTM #EMEA #EMEAE #EMRG #ENER #ENFF #Eng #Gen #IL #ＩＱ #IR #JFOR #JLN #kw #MEAST #MEASTE #NAMER #News #News① #NUCL #OILG #om #POL #Q&A #SA #SECUR #SWASIA #TGLF #TRN #us #War #World #WorldNews #ye #ニュース #世界 #世界ニュース
レバノン、イスラエルとの協議に向け一時停戦提唱 米に仲介・保証役求める | ロイター https://www.yayafa.com/2777312/ ##LB #Ae #AMERS #Asia #ASXPAC #BH #BISV #BMAT #BreakingNews #CWP #Def #DEST:NOJPTPM #DEST:NOJPWDM #DEST:NOJPZTM #dip #EMEA #EMEAE #EMRG #ENER #ENFF #Eng #fin #FINS #Gen #IL #INVBIS #ＩＱ #IR #Israel #JFOR #JLN #kw #MEAST #MEASTE #MINE #MTAL #NAMER #News① #NUCL #OILG #om #PK #POL #Q&A #SA #SASIA #SECUR #SWASIA #TGLF #TRN #us #War #ye #イスラエル #速報ニュース
COREandCO🎤Drapeau noir, cinéma, line-up et métissage musical, 𝗞𝗿𝗮𝘃 𝗕𝗼𝗰𝗮 a répondu à nos questions dans cette interview agrémentée des photos de 𝗟𝘂𝗰𝗶𝗲 𝗠𝗮𝗹𝗳𝗮𝗶𝘁 ...
https://www.coreandco.fr/interviews/krav-boca-march-2026-441.html
エロ本セールナビ
