Show threadVictoria Stuart 🇨🇦 🏳️‍⚧️Sep 25, 2024

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis
https://www.nature.com/articles/s41556-021-00641-w

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Understudied protein blobs have global effects on cell biochemistry
https://phys.org/news/2024-09-understudied-protein-blobs-global-effects.html
https://news.ycombinator.com/item?id=41602473

Biomolecular condensates regulate cellular electrochemical equilibria
https://www.cell.com/cell/abstract/S0092-8674(24)00909-7

#biology #biochemistry #electrochemistry #ProteinChemistry #BiomolecularCondensates #MolecularBiology #PhaseSeparation #PhaseLocalization #ProteinBlobs

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis - Nature Cell Biology

Esposito et al. show that TGF-β-induced DACT1 forms biomolecular condensates that sequester CK2 to repress Wnt signalling and modulate bone metastasis in cancer.

Nature
Show threadVictoria Stuart 🇨🇦 🏳️‍⚧️Sep 25, 2024

A Newfound Source of Cellular Order in the Chemistry of Life
Inside cells, droplets of biomolecules called condensates merge, divide and dissolve
Their dance may regulate vital processes
https://www.quantamagazine.org/a-newfound-source-of-cellular-order-in-the-chemistry-of-life-20210107

#biology #biochemistry #ProteinChemistry #BiomolecularCondensates #MolecularBiology #PhaseSeparation #PhaseLocalization #ProteinDroplets

A Newfound Source of Cellular Order in the Chemistry of Life

Inside cells, droplets of biomolecules called condensates merge, divide and dissolve. Their dance may regulate vital processes.

Quanta Magazine
Victoria Stuart 🇨🇦 🏳️‍⚧️Sep 25, 2024

[thread] Biomolecular condensates
https://en.wikipedia.org/wiki/Biomolecular_condensate

* biochemistry - biomolecular condensate: membrane-less subcellular domains
* specialized cellular functions
* composition not controlled by bounding membrane
* form/maintain organization by var. processes
* phase separation of proteins, RNA, biopolymers into colloidal emulsions, gels, liquid crystals, solid crystals, aggregates

#biochemistry #ProteinChemistry #BiomolecularCondensates #PhaseSeparation #PhaseLocalization #ProteinDroplets

Biomolecular condensate - Wikipedia