Show threadVictoria Stuart 🇨🇦 🏳️‍⚧️Sep 25, 2024

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis
https://www.nature.com/articles/s41556-021-00641-w

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Understudied protein blobs have global effects on cell biochemistry
https://phys.org/news/2024-09-understudied-protein-blobs-global-effects.html
https://news.ycombinator.com/item?id=41602473

Biomolecular condensates regulate cellular electrochemical equilibria
https://www.cell.com/cell/abstract/S0092-8674(24)00909-7

#biology #biochemistry #electrochemistry #ProteinChemistry #BiomolecularCondensates #MolecularBiology #PhaseSeparation #PhaseLocalization #ProteinBlobs

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis - Nature Cell Biology

Esposito et al. show that TGF-β-induced DACT1 forms biomolecular condensates that sequester CK2 to repress Wnt signalling and modulate bone metastasis in cancer.

Nature