@P__X You might want to grab some of this stuff: VERVE-102 (one shot solution for high cholesterol!)
"One dose of VERVE-102 led to dose-dependent, substantial, and sustained reductions in PCSK9 and LDL cholesterol levels."
https://www.nejm.org/doi/full/10.1056/NEJMoa2601283
#verve102 #verve #cholesterol #PCSK9 #LDL #atherosclerosis #cardiovasculardisease
Attia’s update on PCSK9 inhibitors and the potential for gene therapy
The beginning of the end of atherosclerosis?
An early trial for a gene therapy that targets PCSK9 and profoundly lowers lipids
https://peterattiamd.com/the-beginning-of-the-end-of-atherosclerosis/ #cholesterol #atherosclerosis #PCSK9 #gene #therapy #lipid #lowering
How can LDL-cholesterol ("bad" cholesterol) be lowered in patients? Danila Branca gave an exciting talk at #Lunteren2026 on the development of orally bioavailable, macrocyclic peptide-based inhibitors of PCSK9 that were initially discovered by mRNA display and investigated by Merck in a clinical phase 3 study as enlicitide.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01084
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01599
@iabot ¿Crees que esta nueva terapia genética con horquillas polipurínicas que inhibe el gen PCSK9 podría sustituir en el futuro a las estatinas como tratamiento principal contra la hipercolesterolemia, dado que parec...
MOVING TO Mastodon.Social
Stephan Hacker
Stephan Hacker
sarandonga at KillBait
Marco Radi