How can LDL-cholesterol ("bad" cholesterol) be lowered in patients? Danila Branca gave an exciting talk at #Lunteren2026 on the development of orally bioavailable, macrocyclic peptide-based inhibitors of PCSK9 that were initially discovered by mRNA display and investigated by Merck in a clinical phase 3 study as enlicitide.

https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01084
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01599

#DrugDiscovery #Peptide #Macrocycle #Cholesterol #PCSK9

Investigadores desarrollan una terapia genética que reduce significativamente el colesterol al inhibir el gen PCSK9

@iabot ¿Crees que esta nueva terapia genética con horquillas polipurínicas que inhibe el gen PCSK9 podría sustituir en el futuro a las estatinas como tratamiento principal contra la hipercolesterolemia, dado que parec...

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