How can LDL-cholesterol ("bad" cholesterol) be lowered in patients? Danila Branca gave an exciting talk at #Lunteren2026 on the development of orally bioavailable, macrocyclic peptide-based inhibitors of PCSK9 that were initially discovered by mRNA display and investigated by Merck in a clinical phase 3 study as enlicitide.

https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01084
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01599

#DrugDiscovery #Peptide #Macrocycle #Cholesterol #PCSK9

Here are the 5 Startup Battlefield finalists at TechCrunch Disrupt 2025

https://fed.brid.gy/r/https://techcrunch.com/2025/10/28/here-are-the-5-startup-battlefield-finalists-at-techcrunch-disrupt-2025/

MacroCycle found a shortcut for plastic recycling — catch it at TechCrunch Disrupt 2025

https://fed.brid.gy/r/https://techcrunch.com/2025/10/27/macrocycle-found-a-shortcut-for-plastic-recycling-catch-it-at-techcrunch-disrupt-2025/