"We examined how these #flavonoids are #oxidized by human #P450 family 1 and 2A #enzymes. Naringenin was principally oxidized at the 3′-position to form eriodictyol by CYP1 enzymes more efficiently than by CYP2A enzymes, and the resulting eriodictyol was further oxidized to two penta-hydroxylated products. In contrast to plant P450 enzymes, these human P450s did not mediate the desaturation of naringenin and eriodictyol to give apigenin and luteolin, respectively."
Optimizing #cytochrome #P450 network for high-level production of #quillaic_acid.
https://phys.org/news/2023-10-optimizing-cytochrome-p450-network-high-level.html
Researchers from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences have developed a combinatorial optimization approach to construct and spatially control a cytochrome P450-cytochrome P450 reductase (CYP-CPR) network in an engineered Saccharomyces cerevisiae strain to boost quillaic acid production.
Study identifies new levers for controlling #plant #biochemistry
Plant biochemists at the U.S. Department of Energy's Brookhaven National Laboratory have discovered a new level of regulation in the biochemical "machinery" that plants use to convert organic carbon derived from photosynthesis into a range of ring-shaped aromatic molecules. The research, just published in the journal Science Advances, suggests new strategies for controlling plant biochemistry for agricultural and industrial applications.
The Pentaxian
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