Optimizing cytochrome P450 network for high-level production of quillaic acid

Researchers from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences have developed a combinatorial optimization approach to construct and spatially control a cytochrome P450-cytochrome P450 reductase (CYP-CPR) network in an engineered Saccharomyces cerevisiae strain to boost quillaic acid production.