OMG - I did not know this -

Epidermal Sensing of Oxygen Is Essential for Systemic Hypoxic Response
https://doi.org/10.1016/j.cell.2008.02.038

I have not yet read the article, nor have I finished watching the video that had me look up the article:

Tissue identity and rejuvenation - going skin deep with Luis Garza!
https://youtu.be/5iEXYrnZsuM?si=1v2t19i1pDgf8MMA

I had to stop everything and post about this since I'm gobsmacked.

How did I not know this?
The implications for chronic illnesses could be huge.

I need to get back to my chores now, I will probably post more on this later.

#biology #medicine
#physiology #OxygenSensing
#hypoxia #dermatology #HBOT

Epidermal Sensing of Oxygen Is Essential for Systemic Hypoxic Response

Skin plays an essential role, mediated in part by its remarkable vascular plasticity, in adaptation to environmental stimuli. Certain vertebrates, suc…

Li-Juan Duan et al. show that #Tailless (TLX) and #hypoxia inducible factor-2α (HIF2α) cooperate to sustain proangiogenic states of retinal #astrocytes in neonatal mice:

https://journals.biologists.com/bio/article/12/1/bio059684/286421/Tailless-and-hypoxia-inducible-factor-2-cooperate

#Retina #Angiogenesis #OxygenSensing #Science #BiologyOpen #Biology #AcademicMastodon

Tailless and hypoxia inducible factor-2α cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice

Summary: Retinal astrocytes lose their ability to support angiogenesis as they mature. Protein–protein interaction between Tlx and HIF-2α maintains retinal astrocytes in their proangiogenic progenitor and immature states.

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