Scientific FrontlineFeb 4
#CADASIL is a hereditary condition caused by #NOTCH3 gene variants that degenerate vascular smooth muscle cells, leading to strokes, white matter changes, and #cognitive decline.
#Neurology #VascularBiology #Neuroscience #Genetics #sflorg
https://www.sflorg.com/2026/02/ns02042602.html
Changes in brain energy and blood vessels linked to CADASIL

Damage to small blood vessels in the hereditary disease CADASIL may disrupt important brain functions in the hippocampus

brozu ▪️Nov 19

Groundbreaking discovery from Italian researchers at University #LaSapienza: they’ve uncovered how genetic and epigenetic mechanisms, driven by #Notch3 protein and #RNA modification, fuel a rare pediatric leukemia (T-cell ALL).

This insight could revolutionize targeted therapies, improving outcomes for youngest patients.

Precision medicine is the future,
stop using #AI for bullsh*t,
use it for this.

#PediatricLeukemia #Genetics #CancerResearch #NHS