I teach medical students that fatty liver disease (MASLD) affects 1 in 3 adults and has limited approved drug treatments.
That may be changing.
Hebrew University researchers found CBD and CBG -- two non-psychoactive cannabis compounds -- reversed fatty liver in mice through "metabolic remodeling."
How? Two mechanisms:
- Boosted phosphocreatine (a "backup battery" for liver energy)
- Restored cathepsins (cellula... https://www.sciencedaily.com/releases/2026/03/260306145616.htm
#MASLD in kidney transplant recipients #KTR is associated with worse patient and graft survival
https://www.kireports.org/article/S2468-0249(26)02709-9/fulltext?rss=yes
🔬 GastroAGI — February 2026 Updates
February updates are live on GastroAGI, covering key areas in gastroenterology and hepatology, including Liver Transplantation, Endoscopy, IBD, GI Oncology, Upper GI disorders, Cirrhosis, and Fatty Liver Disease (MASLD).
Explore more: https://gastroagi.com
How to Use Millets and Local Berries to Reverse Fatty Liver and Diabetes
The Nordic diet, an eating pattern originating from Scandinavian countries…
#dining #cooking #diet #food #MediterraneanDiet #andIndiandietadaptation #fattyliverdisease #fiberrichfoods #indianexpress.com #insulinsensitivity #MASLD #Mediterranean #NatureCommunicationsstudy #Nordicdiet #type2diabetes #wholegrains
https://www.diningandcooking.com/2478423/how-to-use-millets-and-local-berries-to-reverse-fatty-liver-and-diabetes/
How to Use Millets and Local Berries to Reverse Fatty Liver and Diabetes
The Nordic diet, an eating pattern origi…
#dining #cooking #diet #food #mediterranean #MediterraneanDiet #MediterraneanFood #andIndiandietadaptation #fattyliverdisease #fiberrichfoods #indianexpress.com #insulinsensitivity #MASLD #Mediterranean #NatureCommunicationsstudy #Nordicdiet #type2diabetes #wholegrains
https://www.diningandcooking.com/2478423/how-to-use-millets-and-local-berries-to-reverse-fatty-liver-and-diabetes/
🧪 Autoantibodies & MASLD Outcomes
ANA (17%) and ASMA (25%) are common in MASLD.
Their presence signals worse prognosis:
⚠️ ~4× higher risk of liver decompensation
⚠️ >2× higher mortality
Autoantibodies act as markers of immune activation and predict
progression to cACLD.
➡️ Useful for risk stratification & closer monitoring.
🚭 Smoking increases MASLD risk
by 30–41% in a dose-dependent manner; ≥20 pack-years raises risk by ~32%. Passive smoke exposure increases risk by 13%. Mechanisms include oxidative stress, insulin resistance, inflammation, and gut–liver axis disruption.
Quitting smoking for >10 years reduces MASLD risk to levels comparable with non-smokers.
Sorbitol fuels dangerous fatty liver disease in lab study
Key Points
Scientists warn a common sweetener may help cause serious liver disease. A new study in Science Signalling links sorbitol to MASLD in lab tests.
Getty Images / Stock PhotoHow the gut blocks sorbitol
Researchers studied zebrafish and found harm when gut bacteria were depleted. ValidUpdates recently reported Turkish court rules Instagram likes this week.
The team gave antibiotics to reduce gut bacteria in the fish. After this change, sorbitol reached the liver and caused fat buildup.
Normally gut microbes break down sorbitol before it reaches the liver. Loss of that shield let sorbitol travel and harm liver cells.
The authors warn human gut damage could cause the same effect. They call for more study of sorbitol in real diets soon.
What this means for shoppers
The condition MASLD affects many people and often has no symptoms today. Experts say gut health is a rising focus for liver care too.
Public health groups may now reevaluate sorbitol safety in food. See recent commentary on lifestyle and health at Eedris Abdulkareem urges men to marry.
Researchers call for human studies to confirm the zebrafish findings..Until then, people should consider gut health when choosing sweeteners.
Clinicians may start screening patients for gut microbiome problems more often. Simple diet changes and probiotics might help restore gut bacteria.
Food makers could face pressure to label sorbitol content clearly. Regulators may review safety rules for sugar-free additives and sweeteners.
Researchers urge people to avoid unnecessary antibiotics when possible today. That could help keep the microbiome strong and protective against sorbitol.
The study used zebrafish because their liver biology mirrors ours. But scientists note human trials are needed for firm conclusions.
For now, experts recommend varied diets rich in fibre and fermented foods. These foods help feed beneficial gut bacteria and reduce risk.
Public advice may include checking product labels for sorbitol content today. Consumers can choose alternatives with less sugar alcohols when available or advised.
Health groups will watch for follow-up human studies and guidance. News outlets and regulators will likely report new findings quickly to the public
Share to friends#diet #health #liver #masld #microbiome #research #sugarFree #validupdates
Mitochondria in the heart, skeletal muscle, kidney, and liver of individuals with Type 2 diabetes or with fatty liver disease have a diminished ability to produce energy from ketone bodies.
Summary: https://medicalxpress.com/news/2025-11-people-diabetes-fatty-liver-disease.html
Original paper: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00451-7/fulltext
The liver plays a central role in storing and supplying energy to the body. In type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD, commonly referred to as fatty liver disease), mitochondria—the cell's power plants—cannot switch efficiently between fuel sources.
Mediterranean Diet and Exercise Improve Outcomes in MASLD, MASH
Lifestyle changes—specifically the Mediterranean diet and aerobic exercise—can meaningfully improve liver health in patients with metabolic dysfunction–associated steatotic liver disease (MASLD) and metabolic dysfunction–associated stea…
#dining #cooking #diet #food #MediterraneanDiet #lifestylefactors #MASLD/MASH #Mediterranean
https://www.diningandcooking.com/2256915/mediterranean-diet-and-exercise-improve-outcomes-in-masld-mash/
Robert Lufkin MD
BavariaNephro
GastroAGI
Dining and Cooking
Mediterranean Diet
Chiamaka Precious
RDN