Psychedelic Institute Project
Sublingual & Oral Ketamine Research: Efficacy, Dosage, and Treatment for Mental Health
Ongoing review of the literature related to safety and efficacy of ketamine and esketamine by mouth. (DeMarco, 2024) https://psychedelicmentalhealth.net/ketamine-oral-sublingual-research/ #ketamine #ketaminetherapy #ketamineassistedpsychotherapy
https://pubmed.ncbi.nlm.nih.gov/41765199/ Ketamine pharmacotherapy for major depressive disorder: A narrative review (Miller, et al, 2026) “Ketamine pharmacotherapy provides a novel treatment option for major depressive disorder (MDD) and has generated a large, growing body of research regarding its biochemical and clinical properties.” #ketamine #depression #mentalhealth #ketaminetherapy #ketamineassistedpsychotherapy
Ketamine pharmacotherapy for major depressive disorder: A narrative review - PubMed
Ketamine pharmacotherapy provides a novel treatment option for major depressive disorder (MDD) and has generated a large, growing body of research regarding its biochemical and clinical properties. This narrative review summarizes the history of ketamine's development, beginning as a general anesthe …
https://link.springer.com/article/10.1007/s12671-023-02206-4 Psychedelic-Assisted Psychotherapy and Mindfulness-Based Cognitive Therapy: Potential Synergies (2023) - clear role in supporting psychedelic process, particularly in psychedelic-assisted psychotherapy, likely to prove extremely useful in the preparation, dosing and integration phases. #ketamineassistedpsychotherapy #ketamine #psychedelics #psychedelictherapy #psychedelicassistedpsychotherapy #spravato
Psychedelic-Assisted Psychotherapy and Mindfulness-Based Cognitive Therapy: Potential Synergies - Mindfulness
Objectives The mindfulness-informed intervention that has so far received the most attention as an adjunct to psychedelic-assisted psychotherapy is Acceptance and Commitment Therapy (ACT), but little remains known about potential synergies between psychedelic-assisted psychotherapy and mindfulness-based interventions such as Mindfulness-Based Cognitive Therapy (MBCT). This paper examines and evaluates the therapeutic compatibility of MBCT with psychedelic-assisted psychotherapy, and their potential synergies. Methods This study represents a narrative review of the current literature on psychedelic-assisted psychotherapy and MBCT. Results We demonstrate how MBCT targets core processes including acceptance, being present, concentration, decentering and embracing difficulties — and outline why strengthening these capacities with systematic meditation training may prove invaluable during the preparation, dosing and integration phases of psychedelic-assisted psychotherapy. Conclusions MBCT’s emphasis on systematic training in mindfulness meditation and fostering nonjudgmental presence aligns well with the states of consciousness induced by psychedelics, highlighting its potential to enhance various stages of both the psychedelic experience and subsequent integration. By equipping individuals with effective mindfulness and cognitive restructuring techniques, MBCT may offer advantages beyond those provided by ACT, such as the ability to skillfully navigate and manage challenging experiences that can emerge during different phases of the psychedelic experience and integration. This suggests that MBCT’s unique approach may complement psychedelic-assisted psychotherapy in ways that ACT may not fully address, particularly in the context of handling challenging experiences.
Ketamine combined with psychotherapy for treatment-resistant depression: Real-world outcomes and the role of subjective experience (Cohen, et al, 2026) #ketamine #ketamineassistedpsychotherapy #ketaminetherapy #psychedelics #mentalhealth #depression
“Results from this review suggest that adding ketamine to psychotherapy may improve outcomes, but whether a ketamine treatment improves when adding psychotherapy is largely unclear. Therefore, conclusions on its combined effectiveness cannot be drawn based on the studies so far.” (2026 https://www.sciencedirect.com/science/article/pii/S0272735826000152 #ketamine #ketamineassistedpsychotherapy #ketaminetherapy #psychedelics
Ketamine combined with psychotherapy for treatment-resistant depression: Real-world outcomes and the role of subjective experience - PubMed
Ketamine, an N-methyl-d-aspartate antagonist, shows promise for treatment-resistant depression (TRD), with psychedelic doses potentially enhancing efficacy. However, its transient antidepressant effects and the need for repeated infusions raise concerns about optimal duration and long-term safety. T …
https://pubmed.ncbi.nlm.nih.gov/41527475/ #ketamine #ketamineassistedpsychotherapy “improvement in depressive symptoms was observed, despite their severity, in a sample submitted to multiple previous pharmacological strategies.This retrospective study evaluated ketamine infusions combined with psychotherapy in nine patients with treatment-resistant depression at a general hospital. After eight weeks, all participants improved, scores shifting from severe to moderate. Overall, 44% responded to treatment”
Ketamine Combined With Psychotherapy as a Treatment for Resistant Depression in a Public European Hospital - PubMed
In our study, an improvement in depressive symptoms was observed, despite their severity, in a sample submitted to multiple previous pharmacological strategies.This retrospective study evaluated ketamine infusions combined with psychotherapy in nine patients with treatment-resistant depression at a …
Revisión sistemática seguridad y eficacia de la psicoterapia asistida con Ketamina Systematic Review Safety and Efficacy of Ketamine-Assisted Psychotherapy (Lozano & Spinelli, 2023) #uruguay #psicodelicos #psicodelico https://www.researchgate.net/publication/377383210_Systematic_Review_of_Safety_and_Efficacy_of_Ketamine-Assisted_Psychotherapy_Revision_sistematica_seguridad_y_eficacia_de_la_psicoterapia_asistida_con_Ketamina #ketamina #ketamine #terapiaconketamina #KetamineAssistedPsychotherapy
https://psychedelicmentalhealth.net/ketamine-treatment-in-psychiatry-nutt-et-al-2025/ Spotlight: A long, strange trip: Ketamine treatment in psychiatry (Nutt, et al, 2025)
"...mystical experiences were strongly related to immediate and sustained psychiatric benefits at the group level and on an individual, session-by-session basis across the six doses, providing mechanistic support for ketamine-psychotherapy pairings." #ketamine #mentalhealth #depression #ketaminetherapy #psychelic #ketamineassistedpsychotherapy
"...mystical experiences were strongly related to immediate and sustained psychiatric benefits at the group level and on an individual, session-by-session basis across the six doses, providing mechanistic support for ketamine-psychotherapy pairings." #ketamine #mentalhealth #depression #ketaminetherapy #psychelic #ketamineassistedpsychotherapy
Spotlight: A long, strange trip: Ketamine treatment in psychiatry (Nutt, et al, 2025)
"...mystical experiences were strongly related to immediate and sustained psychiatric benefits at the group level and on an individual, session-by-session basis across the six doses, providing mechanistic support for ketamine-psychotherapy pairings."