Show threadJoanna MaselNov 4, 2022
We wanted to know what caused the extraordinarily #LongTermTrends we previously saw: in #IntrinsicStructuralDisorder and in the degree to which hydrophobic #AminoAcids are clustered, as a function of the time elapsed since a Pfam domain originated. https://elifesciences.org/articles/57347 2/11
Universal and taxon-specific trends in protein sequences as a function of age

Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.

eLife