Nonia ParienteThe latest collection of commentary and Essays in @PLOSBiology is devoted to #immunometabolism.
We highlight how the interplay between systemic metabolism and the immune response impact tissue and organismal functions, as well as the therapeutic potential of manipulating immunometabolism.
⚛️ Nicole Chapman and Hongbo Chi advocate for the use of systems biology approaches as discovery tools for new therapeutic targets
💉 Yun Sok Lee investigates the process of metaflammation, the chronic low-grade inflammatory response that occurs in metabolic diseases such as obesity and type 2 diabetes, exploring how systemic changes in metabolism can affect tissue-resident immune cells
🦠 Griffin Gowdy and Alice Prince look at the role of immunometabolites in both driving and combating bacterial infections, with a focus on lung pathogens
🥗 On a more holistic level, Guang Sheng Ling and colleagues suggest a two-pronged approach to target immunometabolism through pharmaceutical and lifestyle interventions, with a focus on cancer
The collection was edited by Claudio Mauro, Lucas Smith and Joanna Clarke
#immunology #metabolism #cancer #aging #inflammation #infection
https://collections.plos.org/collection/facets-of-immunometabolism/
The many facets of immunometabolism
This Collection of articles aims to shine a light on the many facets of immunometabolism, highlighting how molecular and cellular mechanisms impact diverse tissue and organismal functions and the exciting potential for leveraging immunometabolism for therapeutic interventions.
PLOS Biology
Sparwasser Lab
Gabriele Pollara