Jens StaalA nice new #paper where I have played a small part. An extremely surprising finding where mutants in the 5S #ribosomal #RNA #transcription factor #GTF3A causes enhanced #susceptibility to #HSV #virus #infection, leading to #encephalitis. A #pseudogene #transcribed is a #ligand activating #RIG-I.
https://pubmed.ncbi.nlm.nih.gov/36399538/
#fediscience #immunology #science #PID #genetics #signaling #herpes #health
GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141 - PubMed
Herpes simplex virus 1 (HSV-1) infects several billion people worldwide and can cause life-threatening herpes simplex encephalitis (HSE) in some patients. Monogenic defects in components of the type I interferon system have been identified in patients with HSE, emphasizing the role of inborn errors …