LXR-dependent enhancer activation regulates the temporal organization of the liver’s response to refeeding leading to lipogenic gene overshoot

Refeeding after a period of fasting induces a metabolic switch in the liver and can lead to a ’fat overshoot’, where fat mass surpasses pre-fasting levels. The study elucidates the kinetics of transcriptional and chromatin changes induced by refeeding, revealing a lipogenic overshoot program that is regulated by the transcription factor LXRα.