Muninn 🍃Dec 17
Not every drug derived from a parent compound which CYP2D6 poor metabolizers can't take is an example of #evergreening. Sometimes Big Pharma is just trying to serve a niche market, especially when the parent compound is a blockbuster.
Show threadThe Long TailJun 28, 2024
Am currently coming back from holiday to an #Evergreening project for a system with hundreds of clusters, thousands of #K8s hosts and tens of thousands of workloads, and wondering what new hellscapes the team will have uncovered in the last two weeks.
Once more into the breach!
Matthew RimmerMay 22, 2024

US Senators place blame for sky-high drug prices on abuse of the patent system

https://www.nbcnews.com/health/health-news/sky-high-drug-prices-senators-blame-patent-abuse-rcna153350

Democrats and Republicans accused drug-makers of taking advantage of patents to keep cheaper competition off the market.

#patent #access2meds #healthcare #drugs #uslaw #uspol #evergreening #competition

Sky-high drug prices? Senators blame patent abuse

The drug industry’s top lobbying group faced fierce questioning at a Senate Judiciary Committee hearing on Tuesday that explored whether abuse of the patent system is responsible for keeping prescription drug prices sky-high in the United States.

NBC News
Show threadCory DoctorowJan 20, 2024

These companies get billions in research subsidies, invaluable government patent privileges, and near-total freedom to abuse the patent system with #evergreening:

https://pluralistic.net/2023/11/23/everorangeing/#taste-the-rainbow

The most amazing things about monopolies is how the contempt just *oozes* out of them. It's like these guys can't even *pretend* to give a shit. You want guillotines? Because that's how you get guillotines.

5/

Pluralistic: The FTC has Big Pharma’s number (23 Nov 2023) – Pluralistic: Daily links from Cory Doctorow

Show threadCory DoctorowNov 23, 2023

In service to that end, pharma companies have perfected a process called #evergreening, where they dribble out ancillary patents after their initial filing, covering minor reformulations, delivery systems, or new uses.

Evergreening got a moment in the public eye earlier this year, with #JohnGreen's viral campaign to shame #JohnsonAndJohnson out of using evergreening to restrict poor countries' access to #TB medication:

https://armandalegshow.com/episode/john-green-part-1/

20/

John Green vs. Johnson & Johnson (part 1) - An Arm And a Leg

Why writer John Green rallied his fans around a fight over the cost of a tuberculosis drug.

An Arm And a Leg
Show threadCory DoctorowOct 19, 2023

There's plenty wrong with this argument. For one thing, pharma companies use their monopoly winnings to sell drugs, not invent drugs. For every dollar pharma spends on research, it spends three dollars on marketing:

https://www.bu.edu/sph/files/2015/05/Pharmaceutical-Marketing-and-Research-Spending-APHA-21-Oct-01.pdf

And that "R&D" isn't what you're thinking of, either. Most R&D spending goes to "#evergreening" - coming up with minor variations on existing drugs in a bid to extend those patents for years or decades:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680578/

2/

Glyn MoodyApr 5, 2023
Big Win Against #Evergreening For Tuberculosis Sufferers In India, But Will Johnson & Johnson Allow Those In Other Countries To Benefit? - https://www.techdirt.com/2023/04/05/big-win-against-evergreening-for-tuberculosis-sufferers-in-india-but-will-johnson-johnson-allow-those-in-other-countries-to-benefit/ #patents #tb
Big Win Against Evergreening For Tuberculosis Sufferers In India, But Will Johnson & Johnson Allow Those In Other Countries To Benefit?

“Evergreening” refers to the practice by pharmaceutical companies of making small changes to a drug, often about to come off patent, in order to gain a new patent that extends its manufacturer’s mo…

Techdirt
Glyn MoodyFeb 11, 2023
Thanks To #Evergreening And Legal Threats, AbbVie Has Earned $114 Billion Since 2016 From A Drug Whose Key Patent Expired Back Then - https://www.techdirt.com/2023/02/10/thanks-to-evergreening-and-legal-threats-abbvie-has-earned-114-billion-since-2016-from-a-drug-whose-key-patent-expired-back-then/#comments the patent system is not fit for purpose... #humira
Thanks To Evergreening And Legal Threats, AbbVie Has Earned $114 Billion Since 2016 From A Drug Whose Key Patent Expired Back Then

Techdirt has been writing about evergreening — making small changes to a drug, often about to come off patent, in order to gain a new patent that extends its manufacturer’s control over it &#…

Techdirt
Jack Iwashyna 🫁Nov 21, 2022

Reading my new #JohnsHopkins colleague #RaviGupta's paper on new drug formulations in #JAMAHealthForum

https://pubmed.ncbi.nlm.nih.gov/35977259/

Levels of devious #pharma and clever data

Devious + #NewToMe: #Evergreening #ProductHopping

Super Cool #data: #DrugInnovativeness and #Prescrire

Approvals and Timing of New Formulations of Novel Drugs Approved by the US Food and Drug Administration Between 1995 and 2010 and Followed Through 2021 - PubMed

In this cross-sectional study of novel drugs in tablet or capsule form approved by the FDA between 1995 and 2010, manufacturers pursued new formulations of best-selling brand-name drugs and those granted accelerated approval but did so less frequently once generic competitors entered the market. Oth …

PubMed
Dr. Roy Schestowitz (罗伊)Nov 28, 2017
#patent #evergreening by the biggest drug lords in the world (don't worry, they got it all "legalised") https://gnusocial.de/url/4586516
How Patents Have Contributed To The Opioid Crisis

Over at Quartz, there's a very interesting article about how patents may have contributed to the opioid crisis in the US. It's based on a recent paper, May Your Drug Price Be Ever Green, by law professor Robin Feldman (who has done lots of...