Happy to introduce our latest gizmo from the lab: pLSM !
https://www.biorxiv.org/content/10.1101/2023.05.31.543173v1

A big shoutout to our brilliant grad student, Yannan Chen, who led this work.

In short, pLSM is a plug-and-play, cost-effective and easy-to-scale light sheet microscopy platform. More than 20 times cheaper, with imaging quality comparable to high-end systems.

https://github.com/tomerlab/pLSM-Control

#LSFM #preprint #biorxiv #lightsheet #dopamine

The protocol provides the step-by-step experimental methods for our @eLife paper "3D cell neighbour dynamics in growing pseudostratified epithelia" https://elifesciences.org/articles/68135.

See also our Tweetorial:
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RT @DagmarIber
How many neighbours does an epithelial cell have? And how stable are these interactions over time? #epithelialcell #topology #LSFM #SPIM

Check out our latest pre-print: https://www.biorxiv.org/content/10.…
https://twitter.com/DagmarIber/status/1368806675495452672

3D cell neighbour dynamics in growing pseudostratified epithelia

The 3D shape and dynamic organization of epithelial cells are far more complex than previously believed, but can be explained with simple physical principles based on lateral surface energy minimisation.

eLife