LaborjournalJul 22, 2025
Lisa wollte immer nur forschen. Doch als sie ein vielversprechendes #DrugTarget entdeckt, lässt sie der Gedanke nicht mehr los, ein #Startup zu gründen. Und so beginnt ihr Weg durch Patentanmeldung, Finanzierungshürden und Partnersuche … Die ganze Geschichte unter: https://www.laborjournal.de/rubric/essays/essays2025/e25_09.php
PLOS BiologyNov 19, 2024
Niche-targeting of #antimicrobials. @EmmaGlass33 @papinsysbio &co use a computational data-driven approach to #DrugTarget discovery by identifying #metabolic signatures of diverse #pathogens conserved within body sites. Proof-of-principle with stomach-specific pathogens #PLOSBiology https://plos.io/40TewzH
Niche-specific metabolic phenotypes can be used to identify antimicrobial targets in pathogens

The emergence of resistance to traditional antimicrobials increases the need to develop innovative approaches to understanding pathogen function. This study uses a computational data-driven approach to drug target discovery by identifying metabolic signatures of diverse pathogens conserved within body sites. In vitro validation shows that such site-targeted antimicrobials can effectively inhibit stomach-specific pathogens.