The Body Metropolis: An Epic Battle of Superheroes and Supervillains Within Us
#BodyMetropolis #ImmuneSuperheroes #Cytokines #Pathophysiology #DiseaseProgression #CellularNetworks #Cytotoxicity #ScienceIsCool #HealthInnovation #EpicBiology #InnerBattles #ImmuneSystem #SciFiInRealLife
Macular telangiectasia type 2
Macular Telangiectasia Type 2 (MacTel 2) can be monitored with blue light reflectance imaging, which highlights areas of retinal degeneration and structural changes. Over a 1-year follow-up, an increase in the hyperreflectant area indicates disease progression, reflecting the expansion of retinal abnormalities. This imaging modality is crucial for tracking disease evolution. #MacTel2 #BlueLightReflectance #RetinaImaging #DiseaseProgression…
It's not just about the drugs themselves. #DrugDisease and #DiseaseProgression models are also an area in which #Pharmacometrics continues to have an impact - #FDA maintains a list the ones they've developed internally, including examples for #Alzheimers and #Diabetes, although there are many, many more.
https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/division-pharmacometrics
Pharmacometrics rolls up modeling and simulation for #Pharmacokinetics, #Pharmacodynamics, and #DiseaseProgression, with a focus on populations and variability. A major focus is to understand variability in drug response, which can be predictable (e.g. due to differences in body weight or kidney function) or unpredictable (differences between subjects seem random, but likely reflect a lack of knowledge or data).
CITO Greenhouse
Ricardo Leitão Guerra
Justin Wilkins