Scientific FrontlineJan 26
The optimization of solvent osmolarity and viscosity in #Lymphatic Drug Delivery Systems (LDDS) significantly regulates drug #pharmacokinetics and perinodal dynamics to improve treatment of metastatic lymph nodes.
#Biomedical #Pharmaceutical #Oncology #sflorg
https://www.sflorg.com/2026/01/bmed01262601.html
Optimized Solvent Design Improves Lymphatic Drug Delivery to Metastatic Lymph Nodes

Optimizing drug delivery to the lymphatic system is essential for effective cancer treatment

mymedschoolNov 13

Drug interactions may alter metabolism or receptor effects, impacting efficacy and safety. #DrugInteractions #Pharmacology #Pharmacokinetics #Pharmacodynamics #CytochromeP450 #DrugSafety #ClinicalPharmacology #USMLE #MedicalEducation

https://mymedschool.org/portfolio/u01-05-010-types-of-drug-interactions/?utm_source=mastodon&utm_medium=jetpack_social

Pharmacologic Drug Interactions Explained: Additive, Synergistic, Antagonistic, and More | USMLE Step 1 Pharmacology

Learn how to classify pharmacologic interactions with examples — including additive, synergistic, permissive, antagonistic, and tachyphylaxis effects. Perfect for USMLE Step 1, Step 2, and medical pharmacology review.

mymedschool.org
mymedschoolNov 11

Urine pH alters drug elimination by changing ionization, aiding clearance of weak acids or bases. #UrinePH #DrugElimination #Pharmacokinetics #WeakAcids #WeakBases #RenalExcretion #OverdoseManagement #MedicalEducation #USMLE #ClinicalPharmacology

https://mymedschool.org/portfolio/u01-05-006-urine-ph-and-drug-elimination/?utm_source=mastodon&utm_medium=jetpack_social

Urine pH Modification: How NaHCO₃ and NH₄Cl Affect Drug Excretion | Renal Pharmacology

Learn how urine alkalinization and acidification affect the excretion of drugs like phenobarbital, methotrexate, salicylates, TCAs, and amphetamines. Interactive drag-and-drop exercise for medical students and pharmacy learners.

mymedschool.org
mymedschoolNov 11

Drug metabolism modifies drugs via Phase I and II liver reactions to aid detoxification and excretion. #DrugMetabolism #CytochromeP450 #Pharmacokinetics #PhaseI #PhaseII #Pharmacology #Liver #DrugExcretion #MedicalEducation #USMLE

https://mymedschool.org/portfolio/u01-05-004-drug-metabolism/?utm_source=mastodon&utm_medium=jetpack_social

Phase 1 vs Phase 2 Reactions in Drug Metabolism | Pharmacology Made Simple for USMLE

Learn how to classify drug metabolism reactions into Phase 1 and Phase 2. Understand oxidation, reduction, hydrolysis, glucuronidation, and other key conjugation reactions — essential for pharmacology and USMLE exam prep.

mymedschool.org
Victoria Stuart 🇨🇦 🏳️‍⚧️Apr 24, 2025

Cinnamon could affect drug metabolism in the bod
https://www.sciencedaily.com/releases/2025/04/250424165657.htm
https://olemiss.edu/news/2025/4/cinnamon-drug-interactions/index.html

* could interfere with some prescription medications

Evaluation of bioaccessibility, metabolic clearance and interaction with xenobiotic receptors (PXR and AhR) of cinnamaldehyde
https://www.sciencedirect.com/science/article/pii/S2666566224000443

#food #DrugMetabolism #pharmacokinetics #cinnamon #cinnamaldehyde #DietarySupplements

Cinnamon could affect drug metabolism in the body

Cinnamon is one of the oldest and most commonly used spices in the world, but a new study indicates a compound in it could interfere with some prescription medications.

ScienceDaily
Ivi ChocMar 19, 2025

#FYI #rapamycin #alzheimers #pharmacokinetics

"Rapamycin, an mTOR inhibitor used clinically for immunosuppression, shows promise for repurposing in age-related disorders including Alzheimer's disease (AD).
This open-label pilot study investigated the pharmacokinetic properties of weekly oral rapamycin in [...] early-stage AD.
Findings [...] support fixed-dose regimens in future trials."

https://biologists.social/@medrxivpreprint/114188319062962075

medRxiv (@[email protected])

Pharmacokinetic analysis of intermittent rapamycin administration in early-stage Alzheimer's Disease https://www.medrxiv.org/content/10.1101/2025.03.18.25324017

biologists.social
garyFeb 1, 2025
i am using clobetasol sparingly (ok once a day) but it is helping me creep back to semi normalcy? I have used a bevy of other topical steroids and you have to be really careful not to go over the line - one minute it is helping and next minute it is hell...there are a plethora of monoclonal Ab peptides on the way with v good 3rd stage trials results; no miracle cures yet for psoriasis, i think they are still drilling down a bit and all various interleukins/pathways #il23 #pharmacokinetics
Preston Maness ☭Feb 1, 2025

I spent too much time on this not to share it beyond #tumblr.

#thc #healthcare #pharmacology #medicine #metabolism #pharmacokinetics #weed #cannabis #marijuana #vampire #vampires

Giuseppe MichieliJun 28, 2024

A unifying #model to explain frequent #SARS-CoV-2 #rebound after #nirmatrelvir #treatment and limited prophylactic #efficacy https://www.nature.com/articles/s41467-024-49458-9

Here authors develop a mathematical model for viral-immune dynamics & nirmatrelvir #pharmacokinetics and suggest that early treatment preserves susceptible cells & blunts innate immune response without fully eliminating infection. They project that treatment extension for 10 days may overcome this effect.

A unifying model to explain frequent SARS-CoV-2 rebound after nirmatrelvir treatment and limited prophylactic efficacy - Nature Communications

Viral rebound has been observed following treatment with Paxlovid. Here the authors develop a mathematical model for viral-immune dynamics and nirmatrelvir pharmacokinetics and suggest that early treatment preserves susceptible cells and blunts the innate immune response without fully eliminating infection. They project that treatment extension for 10 days may overcome this effect.

Nature
Planetary EcologistApr 7, 2024

Residence time (Ecology 🏞️)

The residence time of a fluid parcel is the total time that the parcel has spent inside a control volume. The residence time of a set of parcels is quantified in terms of the frequency distribution of the residence time in the set, which is known as residence time distribution, or in terms of its average, known as mean reside...

https://en.wikipedia.org/wiki/Residence_time

#ResidenceTime #Ecology #Geochemistry #QueueingTheory #Pharmacokinetics #BiogeochemicalCycle

Residence time - Wikipedia