I expect AirTags sales to skyrocket when all people in USA realize anyone can be abducted. AirTag is handy in the sense you can hide it fairly well and the abducters phone will happily transfer abductees location to the close ones.
Cheap life insurance.
Is it #countermeasure tour time again? It sure is! We’re heading back to British Columbia in a couple of days! Come enjoy some great a cappella music, bonus points if you’re masking. (I’ll be masking up on stage!)
https://www.countermeasuremusic.com/shows/ #acappella #music #bc #tour
07 Mar BC Tour – Whistler at the Maury Young Arts Centre 4335 Blackcomb Way Whistler, British Columbia V8E 0X4 $25 A ticket Buy Ticket 08 Mar BC Tour – Duncan at the Cowichan Performing Arts Centre 2687 James Street Duncan, BC V9L 2X5 $35 A ticket Buy Ticket 09 Mar BC Tour – Vancouver […]
Nightshade and Glaze can be applied to visual works. Are there any equivalent AI ripoff countermeasures for audio or music?
What is the #relationship between #viral #prospecting in #animals and medical #countermeasure development? MedRxIV: https://www.medrxiv.org/content/10.1101/2024.08.09.24311747v1
With #Filoviridae as a case study, we show there is little #evidence to suggest that viral prospecting has accelerated countermeasure development or that systematically discovering novel #zoonotic viruses in animal hosts before they cause human outbreaks has been feasible.
In recent decades, surveillance in nonhuman animals has aimed to detect novel viruses before they 'spill over' to humans. However, the extent to which these viral prospecting efforts have enhanced preparedness for disease outbreaks remains poorly characterized, especially in terms of whether they are necessary, sufficient, or feasible ways to spur medical countermeasure development. We find that several viruses which pose known threats to human health lack approved vaccines and that known viruses discovered in human patients prior to 2000 have caused most major 21st-century outbreaks. With Filoviridae as a case study, we show there is little evidence to suggest that viral prospecting has accelerated countermeasure development or that systematically discovering novel zoonotic viruses in animal hosts before they cause human outbreaks has been feasible. These results suggest that prospecting for novel viral targets does not accelerate a rate-limiting step in countermeasure development and underscore questions about the importance of zoonotic viral discovery for outbreak preparedness. We consider limitations to these conclusions and alternative but related approaches to preparedness and response. ### Competing Interest Statement A.V.A. was an intern for CEPI in 2023 and is a consultant for Centivax, Inc. M.L. is on the Scientific Advisory Board for CEPI. ### Funding Statement M.L. thanks the VK fund for CCDD, Open Philanthropy, and the DALHAP fund for supporting this work. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Data used for this analysis are available in Supplementary Information.
Non #Ebola #Filoviruses: Potential #Threats to Global #Health #Security https://www.mdpi.com/1999-4915/16/8/1179
In this #review, we summarize current #knowledge on non-Ebola filoviruses (#Bombali virus, #Bundibugyo virus, #Reston virus, #Sudan virus, #TaiForest virus, #Marburg virus, #Ravn virus, #Lloviu virus, ... and Dehong virus) and suggest some strategies to accelerate specific #countermeasure development.
Filoviruses are negative-sense single-stranded RNA viruses often associated with severe and highly lethal hemorrhagic fever in humans and nonhuman primates, with case fatality rates as high as 90%. Of the known filoviruses, Ebola virus (EBOV), the prototype of the genus Orthoebolavirus, has been a major public health concern as it frequently causes outbreaks and was associated with an unprecedented outbreak in several Western African countries in 2013–2016, affecting 28,610 people, 11,308 of whom died. Thereafter, filovirus research mostly focused on EBOV, paying less attention to other equally deadly orthoebolaviruses (Sudan, Bundibugyo, and Taï Forest viruses) and orthomarburgviruses (Marburg and Ravn viruses). Some of these filoviruses have emerged in nonendemic areas, as exemplified by four Marburg disease outbreaks recorded in Guinea, Ghana, Tanzania, and Equatorial Guinea between 2021 and 2023. Similarly, the Sudan virus has reemerged in Uganda 10 years after the last recorded outbreak. Moreover, several novel bat-derived filoviruses have been discovered in the last 15 years (Lloviu virus, Bombali virus, Měnglà virus, and Dehong virus), most of which are poorly characterized but may display a wide host range. These novel viruses have the potential to cause outbreaks in humans. Several gaps are yet to be addressed regarding known and emerging filoviruses. These gaps include the virus ecology and pathogenicity, mechanisms of zoonotic transmission, host range and susceptibility, and the development of specific medical countermeasures. In this review, we summarize the current knowledge on non-Ebola filoviruses (Bombali virus, Bundibugyo virus, Reston virus, Sudan virus, Tai Forest virus, Marburg virus, Ravn virus, Lloviu virus, Měnglà virus, and Dehong virus) and suggest some strategies to accelerate specific countermeasure development.
Justin Buzzard
elora
tech news ᳇ eicker.news
Rpsu (326 ppm)
StefanoGaivota
Giuseppe Michieli