⚡ Schizophrenia • Depression • PTSD • Bipolar • Autism • Epilepsy • Alzheimer’s • Addiction
All may share one root cause: collapse of the hippocampal Excitability Margin.
When ΔVmargin shrinks from 20 mV → ≤ 5 mV, ordinary oscillations trigger involuntary emotional replays → vicious loops.
🧠 One mechanism, many disorders.
#Neuroscience #Psychiatry #BrainHealth #ComputationalModel #MentalHealthResearch
4- More recently: thread on our review of #SplitterCells (a subset of #PlaceCells) where we try to summarize and make sense of many studies, asking if they might support decision-making, or which type of #ComputationalModel might support their firing:
https://elduvelle.github.io/ElDuvelle/status/1556036545223745538/
The associated paper:
Temporal context and latent state inference in the hippocampal splitter signal
It seems like a combination of two types of models - Latent State models and Temporal Context models - might best suit the hippocampal Splitter Signal.. but (IMO) it doesn't look like Splitter cells are really doing anything for actual, immediate decision-making.
4/x
The rodent hippocampus is amazing: place cells, time cells, reward cells...Did you know about the puzzling #SplitterCells?We sought to understand them in an experimental & computational review on temporal context & latent state models!Preprint: https://psyarxiv.com/9z4wr/ 1/25
Referenced link: https://techxplore.com/news/2023-06-mimics-humans-ability-emotions.html
Discuss on https://discu.eu/q/https://techxplore.com/news/2023-06-mimics-humans-ability-emotions.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/TechXplore_com/status/1665734326699577346#m
RT by @physorg_com: #Computationalmodel mimics humans' ability to predict emotions @MIT https://royalsocietypublishing.org/doi/10.1098/rsta.2022.0047 https://techxplore.com/news/2023-06-mimics-humans-ability-emotions.html
When interacting with another person, you likely spend part of your time trying to anticipate how they will feel about what you're saying or doing. This task requires a cognitive skill called theory of mind, which helps us to infer other people's beliefs, desires, intentions, and emotions.
"Implicit Transfer Operator Learning: Multiple Time-Resolution Surrogates for Molecular Dynamics"
https://arxiv.org/abs/2305.18046
#MolecularDynamics #ComputationalModel #SurrogateModel #TimeScale #Simulation #DiffusionModel
Computing properties of molecular systems rely on estimating expectations of the (unnormalized) Boltzmann distribution. Molecular dynamics (MD) is a broadly adopted technique to approximate such quantities. However, stable simulations rely on very small integration time-steps ($10^{-15}\,\mathrm{s}$), whereas convergence of some moments, e.g. binding free energy or rates, might rely on sampling processes on time-scales as long as $10^{-1}\, \mathrm{s}$, and these simulations must be repeated for every molecular system independently. Here, we present Implict Transfer Operator (ITO) Learning, a framework to learn surrogates of the simulation process with multiple time-resolutions. We implement ITO with denoising diffusion probabilistic models with a new SE(3) equivariant architecture and show the resulting models can generate self-consistent stochastic dynamics across multiple time-scales, even when the system is only partially observed. Finally, we present a coarse-grained CG-SE3-ITO model which can quantitatively model all-atom molecular dynamics using only coarse molecular representations. As such, ITO provides an important step towards multiple time- and space-resolution acceleration of MD. Code is available at \href{https://github.com/olsson-group/ito}{https://github.com/olsson-group/ito}.
It might be fun to develop an agent-based #ComputationalModel of social #network dynamics to #model the #TwitterMigration
The parameters of the model could then be updated on the fly via #Bayesian inference 😎
Or maybe, the current situation could be used to test critical predictions derived from existing models...
patrykrosa
El Duvelle Neuro
Phys.org
Dominic Boutet
El Duvelle
Xenia Schmalz
Daniel Heck