Predicting the effect of micro-stimulation on macaque prefrontal activity based on spontaneous circuit dynamics

A crucial challenge in targeted manipulation of neural activity is to identify perturbation sites whose stimulation exerts significant effects downstream with high efficacy, a procedure currently achieved by labor-intensive trial and error. It is demonstrated that the effects of electrical microstimulation on neural activity in the prefrontal cortex of alert monkeys can be predicted solely based on the functional connectivity estimated from cortical recordings at rest.