Mastodawn

#ChemicalProbes #ChemicalProteomics #ProteoProbes #ChemSky #ChemBio #Ligandability #Cysteine #CovalentInhibitor

Interesting ChemRxiv preprint by the group of Katrin Rittinger. They use enantiomeric pairs of covalent inhibitors to profile ligandable cysteines in the proteome. Interesting use of machine learning to predict new compounds that can add most to the ligandable space.

https://doi.org/10.26434/chemrxiv.15002030/v1

#ChemicalProbes #ChemicalProteomics #ProteoProbes #Chemistry #ChemBio #Ligandability #Cysteine #CovalentInhibitor

alexeyorlov Dec 24, 2022

A nice themed collection on #chemicalprobes from #rsc

https://pubs.rsc.org/en/journals/articlecollectionlanding?sercode=md&themeid=9cdafcd3-4776-46b1-a8bc-f1edafeb993d

Chemical Probes Home

Chembellenie Dec 19, 2022

Our chemical tool #BCL6 #degrader is now available for free from the SGC as part of their donated chemical probes programme. We are very pleased to support this initiative which enables researchers to access quality tool compounds for their research. Remarkably, this is the first approved degrader on their list, with no doubt many more to follow! https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/CCT369260 #chemicalprobes #medchem #DrugDiscovery #tpd