Molecular Biology & EvolutionNov 20

Aharonoff et al. show that dosage compensation mechanisms continue to evolve in species with shared X chromosome ancestry, and that the process of evolving chromosome-wide gene regulatory mechanisms is constrained.

🔗 https://doi.org/10.1093/molbev/msaf270

#evobio #molbio #celegans

Parallel Evolution of X Chromosome-Specific Structural Maintenance of Chromosomes Complexes in Two Nematode Lineages

Abstract. Mechanisms of X chromosome dosage compensation have been studied in model organisms with distinct sex chromosome ancestry. However, the diversity

OUP Academic
eLifeOct 27
NeuroSC is a new #OpenAccess tool that lets researchers interactively explore neuronal morphology, membrane contacts and synaptic connectivity across #CElegans development.
https://elifesciences.org/articles/103977?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Albert CardonaOct 24

"The dopaminergic system of Caenorhabditis elegans", Muralidhara and Hardege, 2025
https://royalsocietypublishing.org/doi/10.1098/rsos.250843

That's the review I was waiting for – finally I have the field laid out to write the reinterpretation of part of the worm's pharyngeal ring – aka the brain – as an antennal lobe and a mushroom body.

#Celegans #neuroscience #dopamine

Show threadAlbert CardonaOct 16

@brembs

For the worm there's the additional problem that the field has been working with point neurons for decades, ignoring the fact that most neurons in C. elegans have a very clear axon separate from its dendrite. I'd like to see a cleaned up connectome where there are 4 synaptic connectivity matrices and not one (axo-dendritic, axon-axonic, etc.), and I fear I may have to do so myself.

Modeling a connectome while mixing axo-dendritic with axo-axonic synapses with a point-neuron model is only asking for trouble and confusion.

#Celegans #neuroscience #connectomics

eLifeOct 11
When its meal turns toxic, the tiny worm #CElegans shuts down digestion thanks to a single protein that links its “taste” neurons to the gut.
https://elifesciences.org/digests/104028/gut-feeling?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Gut feeling

C. elegans uses a protein located in specific neurons to detect toxic food and shut down the digestive system.

eLife Sciences Publications, Ltd
PLOS BiologyOct 9
Nicotine exposure elicits diverse behavioral changes. This study shows that in #Celegans, chronic #nicotine exposure couples reversal behaviors to rhythmic body contractions by modulating the sensitivity of a mechanosensory-motor circuit
@PLOSBiology plos.io/4o2CWyS
PLOS BiologyOct 1
How do #neurons maintain adequate lysosomal function during adulthood? This study shows that basal HLH-30 activity is essential for maintaining neuronal #lysosomal function & structural integrity in #Celegans, protecting against aging-related dendritic defects @PLOSBiology https://plos.io/4nU79QF
PLOS BiologySep 25
Xanthine dehydrogenase mutations can cause #xanthinuria in humans. This study in #Celegans provides new insights into the mechanisms of #xanthine #KidneyStone accumulation, implicating sulfate imbalance & osmotic stress in disease progression @PLOSBiology https://plos.io/4pXOCFh
Albert CardonaSep 16, 2025

Postdoc available in Iris Hardege in Cambridge University, UK:

On dopamine receptors in C. elegans:
https://www.cam.ac.uk/jobs/research-associate-neuroscience-research-group-fixed-term-pf47153

#neuroscience #dopamine #Celegans #PhDJobs

Research Associate - Neuroscience Research Group (Fixed Term)

Post Doctoral Research Associate in Neuroscience (Fixed Term) Are you excited by the mechanisms of neurotransmission and behaviour and looking for a new

University of Cambridge
Show threadV4SDBSep 6, 2025
Last talk of the session is by Allan Akandwanaho from the Institute of Molecular Genetics of the Czech Academy of Sciences, who will give a talk on Converting Molecular-Scale Torques to Cellular-Scale Chiral Counter-Rotatory Flows.
#V4SDB2025 #developmentalbiology #celegans