Mastodawn

When the cell’s recycling stations, the lysosomes, start leaking, it can become dangerous. Toxic waste risks spreading and damaging the cell. Now, researchers at Umeå University have revealed the #molecular sensors that detect tiny holes in #lysosomal membranes so they can be quickly repaired
#Biochemistry #sflorg
https://www.sflorg.com/2026/01/bchm01102601.html

New study shows how the cell repairs its recycling stations

Lysosomes are the cell’s recycling stations, handling cellular waste

PLOS Biology Oct 1

How do #neurons maintain adequate lysosomal function during adulthood? This study shows that basal HLH-30 activity is essential for maintaining neuronal #lysosomal function & structural integrity in #Celegans, protecting against aging-related dendritic defects @PLOSBiology https://plos.io/4nU79QF

CellBioNews May 9, 2024

Exploring #lysosomal biology: Current approaches and methods.

#cells #organelles #metabolism

https://phys.org/news/2024-05-exploring-lysosomal-biology-current-approaches.html

Exploring lysosomal biology: Current approaches and methods

Lysosomes are critical for cellular degradation, characterized by their acidic pH and array of hydrolytic enzymes. They degrade materials through endocytosis, phagocytosis, and autophagy, recycling essential components. Lysosomes also participate in vital cellular processes, and their dysfunction contributes to diseases such as lysosomal storage diseases, neurodegenerative disorders, and cancer.

Phys.org

katch wreck Nov 26, 2023

"Here, we demonstrate that damaged #lysosomal #membranes are repaired by #microautophagy (a process termed “microlysophagy”) and identify key regulators of the first and last steps. We reveal the AGC #kinase STK38 as a novel microlysophagy regulator...microlysophagy is regulated by STK38 and GABARAPs and could be essential for maintaining lysosomal integrity and preventing #aging."

https://www.embopress.org/doi/full/10.15252/embr.202357300

#autophagy