Agree to Disagree! - Gene Editing and the Spectre of Eugenics - Watch the full documentary | ARTE in English

Is it possible to modify our genes? Science has made major advancements, such as human DNA sequencing and the CRISPR/Cas9 techniques. While it has become possible to cure genetic diseases and preventively treat predispositions to certain pathologies, these innovations are not without risks and are likely to be misused.

Agree to Disagree! - Gene Editing and the Spectre of Eugenics - Watch the full documentary | ARTE in English

Is it possible to modify our genes? Science has made major advancements, such as human DNA sequencing and the CRISPR/Cas9 techniques. While it has become possible to cure genetic diseases and preventively treat predispositions to certain pathologies, these innovations are not without risks and are likely to be misused.

ARTE

Turku Bioscience Genome Editing Core is organizing a workshop on generating knock-out and knock-in modification using CRISPR/Cas9 technology with in vitro ribonucleoprotein complex delivery.

Read more & apply here: https://bioscience.fi/events/crispr-workshop-2026/

#geneediting #crispr #cas9 https://bsky.app/profile/turkubioscience.bsky.social/post/3me76raw4lk2n #utu #yliopisto

CRISPR workshop 2026

Turku Bioscience Genome Editing Core is organizing a workshop on generating knock-out and knock-in modification... March 23, 2026 - March 27, 2026 @ 9:00 am - 4:00 pm - Turku Bioscience Genome Editing Core is organizing a workshop on generating knock-out and knock-in modification using CRISPR/Cas9 technology with in vitro ribonucleoprotein complex delivery. During the course, participants will learn how to create specific genetic modifications with the CRISPR/Cas9 system, aspects of designing gRNAs and homology-directed repair templates, and they will gain hands-on experience by [...]

🧬 CRISPR technology is transforming genetics πŸ”¬, enabling precise gene editing for research, diagnostics, and future therapeutic innovations πŸš€.

#CRISPR #GeneEditing #Biotechnology #MolecularBiology #Cas9 #Genomics #LifeScienceStudents #ResearchInnovation #BiotechTrends #BioResire

ΠšΡ€ΠΎΠΈΠΌ Π”ΠΠš Π½Π° Python β€” CRISPR gRNA finder, Π§Π°ΡΡ‚ΡŒ II: Π‘ΠΊΠΎΡ€ΠΈΠ½Π³, off-target ΠΈ Ρ€Π΅Π°Π»ΡŒΠ½Ρ‹ΠΉ Π³Π΅Π½

Π’ ΠΏΠ΅Ρ€Π²ΠΎΠΉ части ΠΌΡ‹ написали Π±Π°Π·ΠΎΠ²Ρ‹ΠΉ поиск gRNA с Ρ„ΠΈΠ»ΡŒΡ‚Ρ€Π°Ρ†ΠΈΠ΅ΠΉ ΠΏΠΎ GC-составу. Π Π°Π±ΠΎΡ‚Π°Π΅Ρ‚, Π½ΠΎ Ρ‚ΡƒΠΏΠΎ: всС ΠΊΠ°Π½Π΄ΠΈΠ΄Π°Ρ‚Ρ‹ Π² Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½Π΅ 40-60% ΡΡ‡ΠΈΡ‚Π°ΡŽΡ‚ΡΡ Ρ€Π°Π²Π½ΠΎΠ·Π½Π°Ρ‡Π½Ρ‹ΠΌΠΈ. Π’ Ρ€Π΅Π°Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ это Π½Π΅ Ρ‚Π°ΠΊ. БСгодня Π΄ΠΎΠ±Π°Π²ΠΈΠΌ систСму скоринга β€” Π±ΡƒΠ΄Π΅ΠΌ Ρ€Π°Π½ΠΆΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ gRNA ΠΏΠΎ качСству, учитывая ΠΏΠΎΠ·ΠΈΡ†ΠΈΡŽ Π½ΡƒΠΊΠ»Π΅ΠΎΡ‚ΠΈΠ΄ΠΎΠ² ΠΈ особСнности U6-ΠΏΡ€ΠΎΠΌΠΎΡ‚ΠΎΡ€Π°. ΠŸΠΎΡ‚ΠΎΠΌ ΠΏΠΎΠ΄ΠΊΠ»ΡŽΡ‡ΠΈΠΌ NCBI BLAST, Ρ‡Ρ‚ΠΎΠ±Ρ‹ ΠΏΡ€ΠΎΠ²Π΅Ρ€ΡΡ‚ΡŒ ΠΊΠ°Π½Π΄ΠΈΠ΄Π°Ρ‚ΠΎΠ² Π½Π° off-target: Π½Π΅ ΠΏΠΎΡ€Π΅ΠΆΠ΅Ρ‚ Π»ΠΈ Cas9 Ρ‡Ρ‚ΠΎ-Π½ΠΈΠ±ΡƒΠ΄ΡŒ лишнСС Π² Π³Π΅Π½ΠΎΠΌΠ΅. Π’Π΅ΡΡ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π±ΡƒΠ΄Π΅ΠΌ Π½Π° Π³Π΅Π½Π΅ CCR5 β€” Ρ‚ΠΎΠΌ самом, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΉ ΠΎΡ‚Ρ€Π΅Π΄Π°ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Π» китайский ΡƒΡ‡Ρ‘Π½Ρ‹ΠΉ Π₯э Π¦Π·ΡΠ½ΡŒΠΊΡƒΠΉ Π² скандальном экспСримСнтС 2018 Π³ΠΎΠ΄Π°.

https://habr.com/ru/articles/982876/

#Π΄Π½ΠΊ #cas9 #crispr #Π³Π΅Π½Π΅Ρ‚ΠΈΠΊΠ° #гСнная_инТСнСрия #Π±ΠΈΠΎΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠΊΠ° #биоинТСнСрия #Π°Π½Π°Π»ΠΈΠ·_Π΄Π½ΠΊ

ΠšΡ€ΠΎΠΈΠΌ Π”ΠΠš Π½Π° Python β€” CRISPR gRNA finder, Π§Π°ΡΡ‚ΡŒ II: Π‘ΠΊΠΎΡ€ΠΈΠ½Π³, off-target ΠΈ Ρ€Π΅Π°Π»ΡŒΠ½Ρ‹ΠΉ Π³Π΅Π½

CRISPR-Cas9 Π§Π°ΡΡ‚ΡŒ I: Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈ Π±Π°Π·ΠΎΠ²Ρ‹ΠΉ поиск Π§Π°ΡΡ‚ΡŒ II: Π‘ΠΊΠΎΡ€ΠΈΠ½Π³, off-target ΠΈ Ρ€Π°Π±ΠΎΡ‚Π° с Ρ€Π΅Π°Π»ΡŒΠ½Ρ‹ΠΌΠΈ Π΄Π°Π½Π½Ρ‹ΠΌΠΈ (Π²Ρ‹ Ρ‚ΡƒΡ‚Π°) Π’ ΠΏΠ΅Ρ€Π²ΠΎΠΉ части ΠΌΡ‹ Ρ€Π°Π·ΠΎΠ±Ρ€Π°Π»ΠΈΡΡŒ с Π±Π°Π·ΠΎΠ²ΠΎΠΉ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ CRISPR-Cas9 ΠΈ написали CLI-ΡƒΡ‚ΠΈΠ»ΠΈΡ‚Ρƒ...

Π₯Π°Π±Ρ€

ΠšΡ€ΠΎΠΈΠΌ Π”ΠΠš Π½Π° Python: CRISPR gRNA finder, Π§Π°ΡΡ‚ΡŒ I: Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈ Π±Π°Π·ΠΎΠ²Ρ‹ΠΉ поиск

НСсколько Π»Π΅Ρ‚ Π½Π°Π·Π°Π΄ я наткнулся Π½Π° ΡΡ‚Π°Ρ‚ΡŒΡŽ ΠΏΡ€ΠΎ CRISPR‑Cas9 ΠΈ домашниС Π±ΠΈΠΎΠ»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€ΠΈΠΈ β€” люди Π±ΡƒΠΊΠ²Π°Π»ΡŒΠ½ΠΎ Ρƒ сСбя Π΄ΠΎΠΌΠ° экспСримСнтировали с Ρ€Π΅Π΄Π°ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π³Π΅Π½ΠΎΠ². Π― бэкСнд‑разработчик, биологию послСдний Ρ€Π°Π· ΠΎΡ‚ΠΊΡ€Ρ‹Π²Π°Π» Π² школС, Π½ΠΎ ΠΆΠ΅Π»Π°Π½ΠΈΠ΅ Ρ€Π°Π·ΠΎΠ±Ρ€Π°Ρ‚ΡŒΡΡ Π½ΠΈΠΊΡƒΠ΄Π° Π½Π΅ дСлось. Π’ этой ΡΡ‚Π°Ρ‚ΡŒΠ΅ разбСрёмся, ΠΊΠ°ΠΊ Ρ€Π°Π±ΠΎΡ‚Π°Π΅Ρ‚ CRISPR Π½Π° минимальном ΡƒΡ€ΠΎΠ²Π½Π΅, ΠΈ напишСм CLI‑утилиту Π½Π° Python для поиска ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… guide RNA β€” Β«Π½Π°Π²ΠΎΠ΄Ρ‡ΠΈΠΊΠΎΠ²Β» для молСкулярных Π½ΠΎΠΆΠ½ΠΈΡ† Cas9.

https://habr.com/ru/articles/982664/

#Π±ΠΈΠΎΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠΊΠ° #биоинТСнСрия #cas9 #crispr #Π΄Π½ΠΊ #Π°Π½Π°Π»ΠΈΠ·_Π΄Π½ΠΊ #Ρ‡Π°ΠΉΠ½ΠΈΠΊΡ‡Π°ΠΉΠ½ΠΈΠΊΡƒ

ΠšΡ€ΠΎΠΈΠΌ Π”ΠΠš Π½Π° Python: CRISPR gRNA finder, Π§Π°ΡΡ‚ΡŒ I: Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈ Π±Π°Π·ΠΎΠ²Ρ‹ΠΉ поиск

CRISPR-Cas9 Π§Π°ΡΡ‚ΡŒ I: Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈ Π±Π°Π·ΠΎΠ²Ρ‹ΠΉ поиск (Π²Ρ‹ Ρ‚ΡƒΡ‚Π°) Π§Π°ΡΡ‚ΡŒ II: Π‘ΠΊΠΎΡ€ΠΈΠ½Π³, off-target ΠΈ Ρ€Π°Π±ΠΎΡ‚Π° с Ρ€Π΅Π°Π»ΡŒΠ½Ρ‹ΠΌΠΈ Π΄Π°Π½Π½Ρ‹ΠΌΠΈ (скоро) Как я Π΄ΠΎΡˆΡ‘Π» Π΄ΠΎ ΠΆΠΈΠ·Π½ΠΈ Ρ‚Π°ΠΊΠΎΠΉ? НСсколько Π»Π΅Ρ‚ Π½Π°Π·Π°Π΄ я наткнулся Π½Π° ΡΡ‚Π°Ρ‚ΡŒΡŽ ΠΏΡ€ΠΎ...

Π₯Π°Π±Ρ€
On this day in 2005: CRISPR noted to provide immunity and degrade DNA as means to prevent infection #CRISPR #Cas9 #ThisDayInBiotech

Genetic Engineering Will Change Everything Forever – CRISPR

https://tube.blueben.net/w/pwWTSYPFTfMReWVZx4zZyr

Genetic Engineering Will Change Everything Forever – CRISPR

PeerTube

Reprogramming site-specific retrotransposon activity to new DNA sites.

#Transposons #Retrotransposons #R2 #Cas9 #GenomeEditing

https://www.nature.com/articles/s41586-025-08877-4

Reprogramming site-specific retrotransposon activity to new DNA sites - Nature

A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large payload insertions.

Nature
SciTech Chronicles. . . . . . . . .Feb 15th, 2025

  You can’t manage what you don’t measure. Vol II No 41 274 links Curated Antibiotic-resistant strains of a harmful bacteria thrive in a dia...

Researchers at the Broad Institute of MIT and Harvard and Cyrus Biotechnology have now #engineered two #CRISPR nucleases, #Cas9 and #Cas12, to mask them from the #immune system.
#Biotechnology #Biomedical #sflorg
https://www.sflorg.com/2025/01/biot01092501.html
Scientists engineer CRISPR enzymes that evade the immune system

The new genome-editing tools could lead to safer, more efficient gene therapies.