Howard Smith MD, AMApr 2, 2025
A novel, bivalent RSV vaccine provides lasting protection against respiratory syncytial viral disease over two rather than only one season. #RSV #bivalent #vaccine #renoir #pfizer #universityrochester
https://www.instagram.com/drhowardsmithreports/reel/DH9MacqsZKC/
Howard G. Smith MD, AM on Instagram: "A Longer-Lasting RSV Vaccine A novel, bivalent RSV vaccine provides lasting protection against respiratory syncytial viral disease over two rather than only one season. This the result of a phase 3 so-called RENOIR trial that tested 36,862 participants 60 to over 80 years of age at 241 sites in 7 countries. Helmed by University of Rochester infectious disease researchers, it was just reported in the Clinical Infectious Diseases journal. The vaccine, developed by Pfizer, contains both RSV-A and RSV-B antigens. Tested against a placebo, the vaccine provided 88.9% protection from one month after immunization through the first season and 77.8% protection through the second season. The already available monovalent RSV vaccines from both Pfizer and GSK are verified protective for only one season. This bivalent vaccine, named RSVPreF, can be safely and effectively co-administered with both the influenza vaccines and the CoVid vaccines. That provides a comprehensive shield against that trio of potentially deadly viral respiratory diseases in only one visit to your medical team or neighborhood pharmacy. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf061/8006665?login=false https://www.medscape.com/viewarticle/bivalent-rsv-vaccine-shows-sustained-efficacy-and-safety-2025a10006y0 #RSV #bivalent #vaccine #renoir #pfizer #universityrochester"

0 likes, 0 comments - drhowardsmithreports on April 2, 2025: "A Longer-Lasting RSV Vaccine A novel, bivalent RSV vaccine provides lasting protection against respiratory syncytial viral disease over two rather than only one season. This the result of a phase 3 so-called RENOIR trial that tested 36,862 participants 60 to over 80 years of age at 241 sites in 7 countries. Helmed by University of Rochester infectious disease researchers, it was just reported in the Clinical Infectious Diseases journal. The vaccine, developed by Pfizer, contains both RSV-A and RSV-B antigens. Tested against a placebo, the vaccine provided 88.9% protection from one month after immunization through the first season and 77.8% protection through the second season. The already available monovalent RSV vaccines from both Pfizer and GSK are verified protective for only one season. This bivalent vaccine, named RSVPreF, can be safely and effectively co-administered with both the influenza vaccines and the CoVid vaccines. That provides a comprehensive shield against that trio of potentially deadly viral respiratory diseases in only one visit to your medical team or neighborhood pharmacy. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf061/8006665?login=false https://www.medscape.com/viewarticle/bivalent-rsv-vaccine-shows-sustained-efficacy-and-safety-2025a10006y0 #RSV #bivalent #vaccine #renoir #pfizer #universityrochester".

Instagram
Cytology and GeneticsJan 29, 2025
Cytological Assessment of Gamma Induced Multiple Translocation Heterozygote in Sowa (Anethum graveolens L.) - #Anethumgraveolens #aneuploids #bridge #bivalent #laggard #multivalent #pollenmothercells #gammairradiation #translocationheterozygote #Anethum #pollen #PMCs #translocation - https://link.springer.com/article/10.3103/S0095452724040066
Cytological Assessment of Gamma Induced Multiple Translocation Heterozygote in Sowa (Anethum graveolens L.) - Cytology and Genetics

Abstract In this experiment the development of the various chromosomal interchanges in Sowa (Anethum graveolens L.) was accomplished with the help of Gamma irradiations. The pollen mother cells of Anethum graveolens were observed to be perfectly normal in untreated plants and displayed a regular formation of eleven bivalents at diakinesis, followed by normal separation (11:11) at anaphase I. Cytological manifestation of chromosome configurations at diakinesis and metaphase-I exhibited translocation heterozygotes by the formation of either ring or chain of chromosomes in PMCs of Sowa, particularly at higher doses of Gamma irradiation (200 Gy). The translocation lines showed discernible prevalence of rings (56.58%) over chains (43.42%). In chromosomal configuration, PMCs of Irradiated plants, shows the presence of minimum one or more quadrivalent and bivalents, besides this, some PMCs showed other configurations such as trivalents, pentavalents, hexavalent, and octavalent along with variable number of univalents. At diakinesis, stage of PMCs, 2III + 1IX + 2IV + 1II + 1I configuration was observed in maximum (12.88%) followed by 6II + 1IV + 1V + 1I (12.37%) and 1VII + 1V + 2IV + 2I (11.85%). The configuration 1X + 2IV + 2II showed the lowest (5.15%) frequency. However, a variety of anomalies such as unequal separation (34.93%), laggards (21.91%) and bridges (12.32%) were also recorded. Pollen fertility was reduced (41.21 ± 0.19%) in translocation lines as comparison to control plant (98.59 ± 0.25%). Translocation heterozygotes might be used as an initial foundation for developing aneuploids with novel gene combinations.

SpringerLink
Show threadAngelaDec 3, 2023
Which #booster did I even get back in June? 🤔 It seems like ages. I believe it was the #bivalent that came highly recommended. Or maybe it was the Novavax? Ugggh
Giuseppe MichieliOct 26, 2023
[Articles] #Effectiveness of BNT162b2 BA.4/5 #bivalent #mRNA #vaccine against a range of #COVID19 outcomes in a large health system in the #USA: a test-negative case–control study https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00306-5/fulltext?rss=yes
PaperLouseSep 29, 2023

✅ neue #CoronaImpfung 💪💉

Mussten extra schriftlich das Einverständnis geben, dass wir die #Impfung trotz #STIKO Empfehlung (Abstand 12 Mt.) möchten, da die letzte (#bivalent ) 6 Mt. her ist.

Es gibt mehr als genug Gründe inkl. med. Indikationen, die Auffrischung jetzt zu machen.

#SarsCoV2
#Covid19
#CovidIsNotOver
#CovidIsAirborne
#MaskUp
#DieMaskeBleibtAuf
#GetVaccinatedSaveLives

kurtshSep 25, 2023

And just like that...

#teammoderna #covid19 #bivalent #booster #vaccine #eg5

Show threadLorraineSep 24, 2023

And before anybody calls me a conspiracy theorist & my fears as completely unfounded (remember they delayed approval for #Novavax in Fall of 2022 to be approved only AFTER everyone already got their #bivalent vaccines & then SEVERELY limited it to people who only ever had 2 shots so IF you were responsible & got a 3rd shot in 2021, you weren’t eligible) here’s a photo of what #BigPharma cozied up to #POTUS looks like

They all look super thrilled to be there too🙄

Show threadLorraineSep 20, 2023

@ranil @hfentonmudd
Moderna is better than Pfizer b/c #Pfizer ripped off #Moderna tech which is why they had stroke issues w/ #bivalent

Prob is, most of society has such a horrible time w/#mRNA they won’t do it again from what they’ve told me & nobody understands why Novavax is different

#novavax 🔩up BIG b/c they could have been first out but ex-CEO was greedy & awful

This chart is what convinced me to lie my butt off to procure 4 b/c priming is important

Tbh I’d like 2 of the new booster too… 6 months apart & then an annual one but they might go out of business

Problem is, we have a couple new variants these boosters will definitely not cover & we’re sure to get new ones soon

That new Northeastern study validated my hypothesis that everyone who exhibits no caution/flimsy caution is basically asymptomatically spreading 24/7 but only falls ill again when they catch a variant different than what they’ve had before

Some kind of “catch all the Pokémon” game?

What I will say is MatrixM does absolutely boost your #immunesystem

I get colds pretty darn easily & have noticed it does help me fight things off. It does wane too, just over longer time; perhaps 11 months vs. weeks-3 months. Also zero side effects vs mRNA which is primarily the reason vaccine uptake is so dismal..

I wish more people knew the difference between protein vax & mRNA

Personally will never take mRNA again, but decided that long ago in late 2021 after getting Covid 4 months to the day after my 2nd Pfizer

Giuseppe MichieliSep 14, 2023
[Articles] #Efficacy of a #bivalent (D614   B.1.351) #SARS-CoV-2 recombinant protein #vaccine with #AS03 #adjuvant in adults: a phase 3, parallel, randomised, modified double-blind, placebo-controlled trial https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00263-1/fulltext?rss=yes #research #covid19
Carolyn Barber, MDSep 11, 2023

And herein lies the dirty little secret… We all know that the #COVID19 #vaccines aren’t intended to protect vs infection. The rub: last year’s #bivalent vax provided addt’l protection vs hosp/critical illness for only ~2 mos, before effectiveness waned. Frustrating, to say the least.

However, recall that the vaccines have been shown to reduce the chances of developing #LongCovid (varies btwn 15-40%.) So, might want to factor this into your decision-mkg.

Good discussion 1/2