@ScienceScholar

The reason I'm wondering about hydrogen sulfide is because it induces torpor.
I did some searching and found a study suggesting similarities between H2S and donepezil -

"Exogenous H2S up-regulates the expression of ADAM10 and ADAM17 and sAPPα, and effectively reduce the production of Aβ40, Aβ42 and sAPPβ in vitro in PC12. The PI3-K or JNK signal pathway may be involved in the regulation. Donepezil has similar effects as H2S, which involves PI3-K, JNK or p38 MAPK signaling."
https://doi.org/10.1016/j.niox.2012.08.012

So now I'm wondering why donepezil isn't disease modifying in Alzheimer's. However, I found this -

Donepezil delays progression to AD in MCI subjects with depressive symptoms
https://doi.org/10.1212%2FWNL.0b013e3181aa52d3

#donepezil #Aricept #HydrogenSulfide #H2S

@ScienceScholar

This is interesting; I would love to know more about the mechanism. Does it have to do with hydrogen sulfide?

#torpor #hibernation #acetylcholine #acetylcholinesterase #Aricept