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PlanetMedicines Oct 28, 2024

https://pubmed.ncbi.nlm.nih.gov/39461705/ Joint administration of sub-threshold doses of the acetylcholinesterase inhibitor donepezil with those of the NMDA receptor antagonist ketamine improved rats' recognition memory abilities (Metaxia Styla, et al, 2024) #ketamine #alzheimers #psychedelic #psychedelics #memory #neuroscience #donepezil

Joint administration of sub-threshold doses of the acetylcholinesterase inhibitor donepezil with those of the NMDA receptor antagonist ketamine improved rats' recognition memory abilities - PubMed

Alzheimer's Disease (AD) is a serious progressive neurodegenerative illness conducting to the decay of cognitive functions. A few drugs have been approved for the therapy of AD, including the acetylcholinesterase inhibitors (AChEIs) like donepezil. Their efficiency, however, is modest and their appl …

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Rhyothemis Aug 27, 2024

@ScienceScholar

The reason I'm wondering about hydrogen sulfide is because it induces torpor.
I did some searching and found a study suggesting similarities between H2S and donepezil -

"Exogenous H2S up-regulates the expression of ADAM10 and ADAM17 and sAPPα, and effectively reduce the production of Aβ40, Aβ42 and sAPPβ in vitro in PC12. The PI3-K or JNK signal pathway may be involved in the regulation. Donepezil has similar effects as H2S, which involves PI3-K, JNK or p38 MAPK signaling."
https://doi.org/10.1016/j.niox.2012.08.012

So now I'm wondering why donepezil isn't disease modifying in Alzheimer's. However, I found this -

Donepezil delays progression to AD in MCI subjects with depressive symptoms
https://doi.org/10.1212%2FWNL.0b013e3181aa52d3

#donepezil #Aricept #HydrogenSulfide #H2S

P11 Signaling pathways involved in exogenous hydrogen sulfide and donepezil regulation of APP alpha metabolism

To observe the effects of PI3-K, MAPKs and JNK on APP α metabolism treated with exogenous hydrogen sulfide (H2S) and Donepezil in PC12 cell.PC12 cell …