A tip to anyone starting in research/academia.

Power progression is broken. You really have to pay attention to your development, because by default the trajectory seems to look like this:

RT @[email protected]

Here it is: the allosteric map of a protein.
Want to find all the sites to target in your favourite undruggable protein? Here's how you can do it.
>22k biophysical measurements for one protein (KRAS)
Congratulations to @[email protected] and @[email protected]
https://www.biorxiv.org/content/10.1101/2022.12.06.519122v1

🐦🔗: https://twitter.com/BenLehner/status/1601144621396295680

This is another step up for @[email protected] and I know its been a time in R&D. Duplex means getting both strands of a single molecule reading one after the other (using some molecular biology dark arts); calling it *jointly* reduces error by ~an order of magnitude (Q20->Q30).

RT @[email protected]

How good is it? Q30 at any read length 🤯 #NanoporeConf

🐦🔗: https://twitter.com/iiSeymour/status/1600126898155053056

I've seen a number of threads, blog posts, essays, etc., discussing the implications of Large Language Models such as the ChatGPT implementation of GPT3.5.

The worry is that these systems do a decent job at writing answers to fairly specific prompts, in that they bring together multiple elements to form a question. I've included an example below. If I asked a question like this on an exam, I'd give an answer like this full marks.

#teaching #gpt3 #highereducation

Our latest preprint, with @TraceyGloster (Twitter)
and Emma (not on Twitter/Mastodon) - #CAZymes #databases #bioinformatics - could Emma's software help accelerate your own research?

https://www.biorxiv.org/content/10.1101/2022.12.02.518825v1

Not one of the 33 companies participating in a big trial of a 4-day workweek (with no loss in pay) is returning to a standard 5-day schedule. Productivity went up. Revenue went up. Absenteeism and turnover both went down.

"The benefits are significant."
https://www.livemint.com/companies/people/want-a-four-day-work-week-show-the-results-of-research-to-your-boss-11669783677563.html

The greatest #academia hack I ever learned is to just email the author of a paper if you don't have access to the journal.

I found an article I wanted to read for a project, but the publisher wanted $60. I found the author and got a pdf in my inbox a couple hours later.