Mastodawn

New independent modeling study: Sequencing antagonism between anti-CD3 and antigen-specific tolerance in type 1 diabetes. Open + reproducible; illustrative hypothesis, not a cure. https://sethc555.github.io/type1-diabetes-research/ doi:10.5281/zenodo.20804558 #type1diabetes #antiCD3

Sequencing antagonism between anti-CD3 and antigen-specific tolerance in type 1 diabetes

We build the first mechanistic within-host model of an unexplained pre-clinical drug-drug interaction in type 1 diabetes. Foster et al. (2025, NOD mice) reported that anti-CD3 monoclonal antibody (teplizumab-class) reduces the efficacy of antigen-specific (mRNA/peptide) tolerance immunotherapy - yet both are being pushed toward combination use, making sequencing a live clinical question. A three-state ODE in which autoreactive effectors and antigen-specific Tregs form a bistable switch driving beta-cell mass reproduces the Foster antagonism and yields a falsifiable prediction about how to time and sequence the two therapies. Illustrative modeling hypothesis, not validated clinical findings.

sethc555 5d ago

New independent preprint (AI-assisted, fully open + reproducible): a within-host HIV model in which a therapeutic interfering particle coupled to the latent reservoir is predicted to *assist* immune-mediated post-treatment control — extending, not contradicting, Dodd & de Boer (2025). Illustrative modeling hypothesis, not a cure. Read / code / DOI: https://sethc555.github.io/hiv-aids-research/ #HIV #immunology #virology #compbio #mathbio

A reservoir-coupled therapeutic interfering particle can assist immune-mediated HIV-1 post-treatment control: a within-host modeling study

A within-host modeling study: a therapeutic interfering particle (TIP) coupled to latent-reservoir reactivation is predicted to assist immune-mediated HIV-1 post-treatment control — extending, not contradicting, Dodd & de Boer (2025). Illustrative modeling hypothesis, not a cure.

Seth Cope — HIV within-host modeling