Laurent Seroude ๐Ÿ‡ซ๐Ÿ‡ท๐Ÿ‡จ๐Ÿ‡ฆ

94 Followers
105 Following
421 Posts
PhD 1991-95 Toulouse France
Post-Doc 1995-01 Caltech
Associate-Professor Queen's University

Tales from the trenches of scientific publishers, back in the 1980s:

"Oh my dear, you have no idea. I spent several years in the 80s as assistant managing editor of a top peer-reviewed medical journal, and what I learned is that profit is the only thing that matters. In the space of a single year, the number of issues and the number of pages per issue were doubled, even as several of the issues were given over entirely to advertising for specific drugs, all without any of the people holding medical degrees -- the titular editor or the peer reviewers or the subscribers -- making a single objection.

The journal was one of 20 technical journals owned by financial advisors Dun & Bradstreet, sold shortly afterward to Reed International, another similar firm. The front offices looked lush, but the editing was done in a warren of mostly windowless rooms by young women with zero medical training. Most of what we did was harass the actual doctors who were supposed to do the peer review, because they didn't care enough to meet deadlines, and then copy edit their barely readable responses to make them meet minimal editorial standards. And nobody noticed the product was shit. The subscriptions were paid automatically by corporations, the issues went straight onto shelves in those offices where they served as decoration. As far as I could tell, the only people other than the primary authors of the studies who ever read those studies and reviews were me and my co-workers.

Escaping that place to work in a serious news organization was the best decision I ever made, even if it involved taking a more than 50% salary cut." โ€“ by "AngelaMotorman" at https://old.reddit.com/r/todayilearned/comments/11ymxtq/til_in_1982_scientists_resubmitted_published/jd8lcjq/

#ScientificPublishing #academia #publishing

TIL: In 1982, scientists resubmitted published articles to major psychology journals. Almost none of the reviewers noticed that the articles had already been published, and nearly all of the reviewers said the articles had "serious methodological flaws."

Posted in r/todayilearned by u/Metaright โ€ข 159 points and 19 comments

reddit

Using single cell gene expression atlases to generate split-Gal4 lines with exquisite specificity. Nice papers from the Desplan and Perrimon labs.

https://www.pnas.org/doi/10.1073/pnas.2307451120
https://www.pnas.org/doi/10.1073/pnas.2304730120

#Drosophila

Hi Mastodon folks. Twitter is getting quieter so I've clearly lost my previous @scotttishwaddell twitterverse. I'll start posting occasional lab news here too (instead) so please follow if that's of interest. We've lots in the pipeline and I'm missing learning about the other cool science out there that used to flash by my eyes on Twitter. Cheers, Scott. #Introduction #neuroscience #drosophila #dopamine
๐Ÿ“ฐ "The utility and caveat of split-GAL4s in the study of neurodegeneration"
by ๐Ÿ”ฌ Luca Stickley, Rafael Koch, Emi Nagoshi
https://pubmed.ncbi.nlm.nih.gov/36959085/ #DrosophilaMelanogaster
#Drosophila
The utility and caveat of split-GAL4s in the study of neurodegeneration - PubMed

Parkinson's disease (PD) is the second most common neurodegenerative disorder, afflicting over 1% of the population of age 60 y and above. The loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) is the primary cause of its characteristic motor symptoms. Studies using <i>Dr</i> โ€ฆ

PubMed

Boosting this with alt-text because #librarians rule! ๐Ÿ’ช

I love the last panel. ๐Ÿ˜Š

#Libraries #NoLimits #Books #Reading

Absolutely the best Acknowledgments section of a paper Iโ€™ve read. From https://arxiv.org/abs/2302.03988 #astrodon / h/t @playingwithdust
On Cosmological Low Entropy After the Big Bang: Universal Expansion and Nucleosynthesis

We investigate the sensitivity of a universe's nuclear entropy after Big Bang nucleosynthesis (BBN) to variations in both the baryon-to-photon ratio and the temporal evolution of cosmological expansion. Specifically, we construct counterfactual cosmologies to quantify the degree by which these two parameters must vary from those in our Universe before we observe a substantial change in the degree of fusion, and thus nuclear entropy, during BBN. We find that, while the post-BBN nuclear entropy is indeed linked to baryogenesis and the Universe's expansion history, the requirement of leftover light elements does not place strong constraints on the properties of these two cosmological processes.

arXiv.org
Mesmerizing work by the @casa_tuthill lab
---
RT @casa_tuthill
The emerging connectome, or synaptic wiring diagram, of the Drosophila brain has transformed fly circuit neuroscience. But the ventral nerve cord, which mediates limb proprioception and motor control, has lagged behind. We set out to fill this gap. ๐Ÿงต1/n
https://www.biorxiv.org/content/10.1101/2022.12.15.520299v1
https://twitter.com/casa_tuthill/status/1623007274922033152