Pathogen Info

Still adding things, info is found via the menu A good meta thread of threads is https://twitter.com/laurieallee/status/1521178772023652352 which links to high quality sources and 300+ bookmarks https://raindrop.io/JW_Lists/covid-lists-30427555?ref=okdoomer.io

Presentation UnitedtoFight_D. Beckman_2.pdf | Powered by Box

Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system - Nature Biomedical Engineering

Integrated alveolus and blood–brain barrier tissue chips recapitulate neuropathogenesis associated with infection by SARS-CoV-2.

The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys - Signal Transduction and Targeted Therapy

Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19. In rhesus monkey, SARS-CoV-2 invades the CNS primarily via the olfactory bulb. Thereafter, viruses rapidly spread to functional areas of the central nervous system, such as hippocampus, thalamus, and medulla oblongata. The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons, microglia, and astrocytes in the CNS. Consistently, SARS-CoV-2 infects neuro-derived SK-N-SH, glial-derived U251, and brain microvascular endothelial cells in vitro. To our knowledge, this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model, which provides important insights into the CNS-related pathogenesis of SARS-CoV-2.