Mastodawn

Sean Gibbons Jul 11, 2024

Excited to share that Nick Quinn-Bohmann's recent paper is the July cover-article in Nature Microbiology!

Check it out our paper here: https://www.nature.com/articles/s41564-024-01728-4

Cover art (attached) by the amazing Sam D'Orazio, in consultation with Allison Kudla at ISB 🤩

This work was co-supervised by @thaasophobia, & we had help from an amazing team of collaborators.

Microbial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut - Nature Microbiology

Microbial community-scale metabolic modelling predicts person-specific short-chain fatty acid profiles and can be used to estimate the impact of dietary, prebiotic and probiotic interventions.

Nature

Sean Gibbons Sep 8, 2023

I'm excited to announce that the 2023 ISB Virtual Microbiome Series registration site is live!

We will host a 2-day bioinformatic course and a 1-day symposium Oct. 11-13.

This year's theme is 'how the ecology of our guts protects us from pathogens'

https://isbscience.org/microbiome2023/

2023 ISB Virtual Microbiome Series

On October 11 - 13, 2023, ISB will host a virtual course and symposium on how the ecology of our guts protects us from pathogens.

Sean Gibbons May 5, 2023

Proud to announce that @joemyxter and I took the @isbsci cornhole championship trophy home again this year 🌽🏆 🫅

Sean Gibbons May 4, 2023

RT @rossbenjamind
*Very* excited to share our latest paper in which we use metagenomics to understand how microbiome development during early life is altered in infants with cystic fibrosis. Led by @pesalerno and @ajverster https://www.biorxiv.org/content/10.1101/2023.05.02.539134v1 @MCBDartmouth @m2p2_dartmouth @DartCF

Sean Gibbons May 4, 2023

A fine day for the @isbsci annual retreat 🏔️🌞

Photo credit @avcarrology

Sean Gibbons May 2, 2023

RT @cellhostmicrobe
Fuso induces tumor resistance to #immunotherapy. New work reports that Fusobacterium nucleatum-derived succinic acid diminishes sensitivity to anti-PD-1 mAb in #ColorectalCancer by impairing CD8+ #Tcell-mediated antitumor immunity https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00161-0

Sean Gibbons May 2, 2023

RT @cientificolatin
Applying to STEM grad programs? Know someone who is? 🎓

Sign ups are ✨OPEN✨ for #GSMI2023!🤩

The GSMI program supports applicants from minoritized backgrounds through 1-on-1 mentorship, fee waivers, & more!

Applications due 6/15
https://www.cientificolatino.com/gsmi

MORE INFO in 🧵 1/

GSMI (Mentorship Program) | Científico Latino

Learn more about Científico Latino's mentorship program for STEM graduate school applicants. Sign ups are open now!

Científico Latino

Sean Gibbons May 2, 2023

RT @catgyoung
Scientific method finally explained.

Show thread

Sean Gibbons May 1, 2023

Our metabolic model provides detailed mechanistic insights into what factors govern C. diff growth.

We looked at the top metabolites that C. diff consumed across models (i.e., its niche), & found that C. diff clustered into three growth niches: high-, moderate-, and no-growth.

Show thread

Sean Gibbons May 1, 2023

Next, we wanted to assess this engraftment risk index following an FMT treatment. We pulled down pre- and post-FMT sequencing data from https://pubmed.ncbi.nlm.nih.gov/25825673/ and we saw that risk was high pre-FMT and lower post-FMT. However, many healthy individuals were susceptible to C. diff.

Dynamic changes in short- and long-term bacterial composition following fecal microbiota transplantation for recurrent Clostridium difficile infection - PubMed

Dynamic behavior is an intrinsic property of normal fecal microbiota and should be accounted for in comparing microbial communities among normal individuals and those with disease states. This also suggests that more frequent sample analyses are needed in order to properly assess success of FMT proc …

PubMed

lab website	https://gibbons.isbscience.org/
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