For those interested, this screencast provides an overview of how the mutation spectrum can shape evo, in 3 modes (each with its own theory and empirical results)
* deleterious mut pressure
* ultimate source of raw materials
* introduction of novelty
https://www.youtube.com/watch?v=n8Tb2xatUNs
Most people will benefit from the intro video that explains some basic concepts, including the concept of a generative bias, i.e., a bias in the process of generating variation
The latest evol-mut-circle seminar (from last week) is now available
James Horton shares ongoing work combining genetic dissection of a GGGGT hotspot in P. fluorescens with an analysis of Salmonella genomes, exploring the basis of a 1000X enhancement of T-to-G mutation rate
Passcode: ?3H+M@Ph
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Potential post-docs: are you interested the role of mutation in evolution? Please consider applying for a competitive NRC post-doc fellowship (2 yrs, generous salary and benefits, open to US citizens)
Contact me if you are interested
https://www.nist.gov/iaao/academic-affairs-office/postdoctoral-students-nrc-postdocs
dN/dS > 1 is not equivalent to positive selection. It’s suggestive of it.
So the rate of nonsynonymous substitutions was higher than the rate of synonymous substitutions — so what? Without more information, the cause of that difference is underdetermined. #evolution
The next evol-mut-circle seminar is Nov 19 (15:00 UTC) by Nora Martin, "Non-Poissonian Bursts in the Arrival of Phenotypic Variation and their Effect on Adaptation"(reading: https://doi.org/10.1093/molbev/msae085)
DM me to join the mailing list for announcements. Full schedule and info:
www.molevol.org/evol-mut-circle
We are expanding our activities for 2025. More later.
Another excellent evol-mut-circle seminar today by Rose Novick with her insightful and broad account of structuralism and functionalism in evo bio
Zoom recording is linked below (Passcode: W0u!^sig)
DM me with your email to join the list for regular seminars
Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom Rooms is the original software-based conference room solution used around the world in board, conference, huddle, and training rooms, as well as executive offices and classrooms. Founded in 2011, Zoom helps businesses and organizations bring their teams together in a frictionless environment to get more done. Zoom is a publicly traded company headquartered in San Jose, CA.
The recording of the latest evol-mut-circle talk from
@PeterALind
(role of mut bias in experimental adaptation) is now available online. See the full list of upcoming and past talks, with recordings, here:
I’m starting a special interest group with monthly seminars + discussion focused on exploring the role of mutation in evolution, covering #evobio #popgen #histsci #philsci
Upcoming speakers: @PeterALind, Deepa Agashe, Grey Monroe, Rose Novick, Alex Klug
To join the mailing list, email <myfirstname>@umd.edu
The recorded evol-mut-circle talk by @DeepaAgashe is now available (pw = #?HS2x&$)
Planned talks: Alex Klug (role of rare muts in adaptation), Peter Lind (experimental evo under mut bias) and Rose Novick (structuralism and functionalism)
DM me to join
Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom Rooms is the original software-based conference room solution used around the world in board, conference, huddle, and training rooms, as well as executive offices and classrooms. Founded in 2011, Zoom helps businesses and organizations bring their teams together in a frictionless environment to get more done. Zoom is a publicly traded company headquartered in San Jose, CA.
Chase W. Nelson 倪誠志
GenomeBiolEvol