multicellular systems & cancer with #PhysiCell • #COVID19 & immune modeling • #DigitalTwins • #OpenSource • #astrophotography • Associate Professor of Intelligent Systems Engineering at IU Bloomington
(@MathCancer on Twitter) Also: @mathcancer
#fedi22 #compbio #mathonco #mathbio #ABM #agentbasedmodels #HoosierMast
| Website | http://MathCancer.org |
| Verification | http://MathCancer.org/index.php |
Excited to share our paper in @[email protected]: SPICEMIX, a joint model of spatial info and gene exp from spatial transcriptome data. Advances upon NMF w/ integration of graphical model, resulting in more meaningful latent reps of cells and spatial metagenes. https://www.nature.com/articles/s41588-022-01256-z
SpiceMix uses latent variable modeling to infer cell identities by jointly analyzing intrinsic and spatial factors, allowing the identification of spatially variable metagenes and refined cell subtypes.
99.7% illuminated #moon, captured as a 2-panel mosaic from my backyard on January 7, 2023.
I tried to keep a delicate touch in processing, in particular to avoid oversaturation and overbrightening that tends to wash out details. #astrodon #astrophotography
Tech details: https://www.astrobin.com/3sj03t/
Prints available at: https://mathcancer.darkroom.com/products/solar-system/868092
Just finished processing #Comet #C2022E3 ZTH.
This shows 2 hours of travel against the background stars, captured from my Indiana backyard at 4 am this morning.
Note the separate dust and ion tails.
#astrodon #astrophotography #HoosierMast
tech details: https://www.astrobin.com/9a9i6o/
Biosynthesis of organelle precursors is a central part of the organelle size control problem, but what systems are required to control precursor production? Genes encoding flagellar proteins are upregulated during flagellar regeneration in Chlamydomonas, and this upregulation is critical for flagella to reach their final length, but it not known how the cell triggers these genes during regeneration. We present two models based on transcriptional repressor that is either produced in the flagellum, or else is produced in the cell body and sequestered in the growing flagellum. Both models lead to stable flagellar length control and can reproduce the observed dynamics of gene expression. The two models make opposite predictions regarding the effect of mutations that block intraflagellar transport (IFT). Using quantitative measurements of gene expression, we show that gene expression during flagellar regeneration is greatly reduced in mutations of the heterotrimeric kinesin-2 that drives IFT. This result is consistent with the predictions of the model in which a repressor is sequestered in the flagellum by IFT. Inhibiting axonemal assembly has much less effect on gene expression. The repressor sequestration model allows precursor production to occur when flagella are growing rapidly, representing a form of derivative control.
Come work with us! @[email protected] is seeking experienced and self-driven candidates for the role of Head of Research Strategy, Communication, and International Relations.
@[email protected] @[email protected]
🐦🔗: https://twitter.com/AMathelier/status/1609858301994627073
Meredith Whittaker
Dr. Elana Fertig
Peter Lewis
Mary McIntyre Astronomy
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