Paul Macklin
Dr. Elana FertigExcited to share our paper in @[email protected]: SPICEMIX, a joint model of spatial info and gene exp from spatial transcriptome data. Advances upon NMF w/ integration of graphical model, resulting in more meaningful latent reps of cells and spatial metagenes. https://www.nature.com/articles/s41588-022-01256-z
SpiceMix enables integrative single-cell spatial modeling of cell identity - Nature Genetics
SpiceMix uses latent variable modeling to infer cell identities by jointly analyzing intrinsic and spatial factors, allowing the identification of spatially variable metagenes and refined cell subtypes.