Well done to Dr Sherry on brilliantly passing her PhD viva!!! 🎉
ERainero_lab
- 79 Followers
- 73 Following
- 36 Posts
bioRxivThe protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25. https://www.biorxiv.org/content/10.1101/2024.07.08.602517v1?med=mas
New preprint from our lab!! By Shengnan (Sherry) Yuan and Rachele Bacchetti. We found that the small GTPase Rab25 drives the expression of the protease ADAMTS5, which promotes ovarian cancer cell invasion.
https://www.biorxiv.org/content/10.1101/2024.07.08.602517v1
https://www.biorxiv.org/content/10.1101/2024.07.08.602517v1
Our latest review is out!! Macropinocytosis at the crossroad between nutrient scavenging and metabolism in cancer" https://pubmed-ncbi-nlm-nih-gov.sheffield.idm.oclc.org/38626703/#:~:text=Macropinocytosis%20(MP)%2C%20the%20actin,often%20found%20in%20solid%20tumours.
📢 We are recruiting!!! 📢
A 3 year postdoc position is available in my lab to work on a
@BreastCancerNow funded project investigating integrin-dependent #ECMatrix trafficking.
Closing date: 12th March
Apply 👇
https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9NjVDQTkwQTA1M0MxMjBDMkUxMDAwMDAwQUMxRTg4NzgmY2FuZF90eXBlPUVYVA%3d%3d&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=%2fSAP%2fPUBLIC%2fBC%2fUR%2fuos#
RT and DM for more info
@MCB_Sheffield
@TUOS_Cancer
A 3 year postdoc position is available in my lab to work on a
@BreastCancerNow funded project investigating integrin-dependent #ECMatrix trafficking.
Closing date: 12th March
Apply 👇
https://jobs.shef.ac.uk/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?PARAM=cG9zdF9pbnN0X2d1aWQ9NjVDQTkwQTA1M0MxMjBDMkUxMDAwMDAwQUMxRTg4NzgmY2FuZF90eXBlPUVYVA%3d%3d&sap-client=400&sap-language=EN&sap-accessibility=X&sap-ep-themeroot=%2fSAP%2fPUBLIC%2fBC%2fUR%2fuos#
RT and DM for more info
@MCB_Sheffield
@TUOS_Cancer
PLOS BiologyBreast tumors devour ECM to obtain tyrosine. @DrMonaNazemi @ERainero_lab &co show that invasive #BreastCancer cells use #macropinocytosis-dependent uptake and lysosomal degradation of collagen-rich #ECM to promote their growth #PLOSBiology https://plos.io/3OaTjdl
The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism
Breast tumors are embedded in a collagen-rich extracellular matrix (ECM) network, where nutrients are scarce due to limited blood flow and elevated tumor growth. This study shows that invasive breast cancer cells use macropinocytosis-dependent uptake and lysosomal degradation of ECM to promote their growth.
Thanks to
@ReviewCommons +
@PLOSBiology for the very positive review + editorial process & to @CR_UK
for funding!
@MCB_Sheffield
@TUOS_Cancer
@ScienceShef
@ReviewCommons +
@PLOSBiology for the very positive review + editorial process & to @CR_UK
for funding!
@MCB_Sheffield
@TUOS_Cancer
@ScienceShef
Amazing work led by @DrMonaNazemi with @Montse_Llanses, @BianYns
& @collins_lab
(2/3)
& @collins_lab
(2/3)
Excited to share our latest article published in @PLOSBiology: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002406
The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism
Breast tumors are embedded in a collagen-rich extracellular matrix (ECM) network, where nutrients are scarce due to limited blood flow and elevated tumor growth. This study shows that invasive breast cancer cells use macropinocytosis-dependent uptake and lysosomal degradation of ECM to promote their growth.
Internalisation of integrin-bound extracellular matrix modulates invasive carcinoma cell migration https://www.biorxiv.org/content/10.1101/2024.01.11.575153v1?med=mas