4/6 GlycoShape (https://glycoshape.org) is an OA database and toolbox that allows you to restore the 3D structure of glycoproteins with a fast and accurate algorithm named Re-Glyco.
The database counts > 550 glycans to date, largely from the human glycome with examples from all species. For an overview check out the figure below ⬇️
"Wait, I thought you lived in South Africa!" Well, yes, but then we ran into a bit of a challenge.
If you would like to know more about how we decided to come to the #Netherlands this blog post is for you!
https://pickingupthetabb.wordpress.com/2024/10/12/a-peripatetic-proteomics-professional/
In this month's interesting fact about #glyco we learn how #monosaccharides not synthesized by humans/mammals could occur as part of the human/mammalian glycan repertoire.
For more interesting facts check: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans
A spoonful of sugar #11 🍬
As the rest of the community, we are excited about #AF3 and have been testing its performance in the reconstruction of glycans and glycosylation. We have found the following limitations users should be aware of:
- The structure of the Asn-linkages is incorrect
- All N-glycans have an a2 arm, while the Man should be in a3
What we suggest 😜 is to build the protein with AF3 and to reglycosylate it with ReGlyco at https://glycoshape.org 
Excellent review by Pamela Stanley @NatureRevGenet
about genetics of glycosylation. Must-read!
No noise is good noise.
Human Rh associated glycoprotein (RHAG): HPA cell type mRNA distribution + GPMDB cell type protein tabbulation & PeptideAtlas tissue/cell type protein distribution. #proteomics
GlycoShape
Dave Tabb
Patrick van der Wel
⏣ Prof. Oliver Jones
NCFG
Marcin Czerwinski
Magnus Palmblad
Ron Beavis ❌