| Website | https://hoanganhle2602.wixsite.com/cellsandtheirwonders |
| Institution | University College London |
| Research | Cell migration, Mechanobiology, Immunology, Cancer |
Looking like a genius move for @Co_Biologists to launch their Mastodon instance this week.
RT @AdamShellard
Roberto (@mayor_lab) & I wrote a review about some emerging themes related to how stiffness infuences morphogenesis.
Thanks very much to the @BiochemSoc for the invitation! #BiochemSocTrans
You can read it here - https://portlandpress.com/biochemsoctrans/article/doi/10.1042/BST20220826/232986/Sculpting-with-stiffness-rigidity-as-a-regulator
From a physical perspective, morphogenesis of tissues results from interplay between their material properties and the mechanical forces exerted on them. The importance of mechanical forces in influencing cell behaviour is widely recognised, whereas the importance of tissue material properties in vivo, like stiffness, has only begun to receive attention in recent years. In this mini-review, we highlight key themes and concepts that have emerged related to how tissue stiffness, a fundamental material property, guides various morphogenetic processes in living organisms.
Salary for this Role: From £39,950, subject to skills and experience Job Title: Senior Laboratory Research Scientist Reports to: Erik Sahai Closing Date: 11/May/2023 23.59 GMT Job Description: Job title: Senior Laboratory Research Scientist Reports to: Erik Sahai, Principle Group Leader – Assistant Research Director Contact term: This is a full-time, fixed term (2 year) position on Crick terms and conditions of employment. Project summary The Senior Laboratory Research Scientist role is to provide support to interlinked projects within the Sahai group. In particular, we are seeking to understand the mechanisms that determine the spatial organisation of tumours and how this is linked to disease progression and therapy responses. To answer these questions, we use a suite of models and tools. These range from the analysis of patient tissue, through pre-clinical models, and in vitro co-culture systems, to in silico modelling of the tumour microenvironment. The project will involve the generation of models and tissue for spatial analysis, and the subsequent imaging and quantitative analysis of the tissue. Perturbations to the tumour systems are likely to include the addition of drugs targeting driver oncogenes, radiotherapy, and immune-modulating agents. Key outputs will be the response of models to therapy and linked quantitative information about either gene expression or the spatial organisation of the tissue. The Research Group Dr Sahai’s laboratory focuses on how the tumour microenvironment influences the spread of cancer and how it responds to therapies. Details of research projects currently being undertaken can be seen at: https://www.crick.ac.uk/research/labs/erik-sahai The research aims to understand the mechanisms determining the composition, organisation, and functionality of the tumour microenvironment - and will contribute to the research funded by an ERC grant. In this project, some of the specific aims could include but not be limited to: Spatial analysis of the tumour microenvironment using highly multiplexed immunostaining Analysis of responses to targeted, radiotherapy, and immunotherapies Establishment and analysis of co-culture models of the tumour microenvironment The Senior Laboratory Research Scientist role is expected to contribute to between 1 and 3 projects at any one time on a collaborative basis (both in the lab and with external collaborators). They are expected to be able to plan, execute, and interpret experiments and provide input into the long-term direction of projects. The ability to work in a team and communicate with other teams is essential. Key responsibilities These include but are not limited to: Collaborating with other lab members on research projects. Providing experimental or technical support to other lab members. Providing technical expertise for the development, refinement and troubleshooting of relevant methodologies. Design and execute experiments using transient- and viral-based expression systems to modulate the activity/expression of target proteins Participating in academic activities, including group meetings and journal clubs, seminars, Organisation and management of the laboratory, including maintaining laboratory databases, ordering of laboratory supplies, monitoring, and routine maintenance of laboratory equipment. Key experience and competencies The post holder should embody and demonstrate our core Crick values: bold, open, and collegial, in addition to the following: Essential PhD in cell or cancer biology, or significant experience. Good knowledge and experience in cancer biology Technical expertise in cell culture, immunostaining of cells or tissues, and fluorescence microscopy Track record of contribution to papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings Experience of experimental design Ability to work independently and also capable of working effectively in a multi-disciplinary team Desirable Experience in research with model biological system Experience in molecular biology and/or highly multiplexed immunostaining Experience in design and delivery of pre-clinical cancer models Experience in quantitative analysis of experimental data using R, Matlab, or similar Has a desire to work in pre-clinical cancer models, respects and has empathy towards the care and use of animals in science Possesses good observational, attention to detail, and record keeping skills Works in a flexible, but organised manner, to meet objectives/deadlines Find out what benefits the Crick has to offer: For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits Equality, Diversity & Inclusion: We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level. Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success. The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices. Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion The Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health. At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases. The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
Stephen Royle