A cancer drug that clears tau: Omipalisib reduces Alzheimer’s-linked protein by revving up cellular cleanup - 1ban.news

The accumulation of hyperphosphorylated tau protein into neurofibrillary tangles is one of the defining pathologies of Alzheimer's disease and related tauopathies such as progressive supranuclear palsy and corticobasal degeneration. For decades, drug developers have tried, and largely failed, to clear tau from the brain. Antibodies, small molecules, antisense oligonucleotides: the approaches have been many, the