Mx Verda
19:20 I wish to offer hugs of Anuhea's preferred squeeziness. Any number of hugs, jfc.
YouTube
Okay so I want this, but buzzed in the back (or close cut with whatever because heads are bumpy) and longer + curly in the front.
Idm bangs or not, as long as they don't rest on my eyelashes.
Then nape is cooler, front can be curly af, and block some of light from sides. Maybe bangs ('fringe') to block top-down light too.
And light warm green, obviously.
https://www.youtube.com/watch?v=mG0G7bWIkwA
https://www.samvilla.com/blogs/hair-tutorials/best-haircutting-techniques
Basic A-Line (Triangular) Bob Haircut Tutorial
Yes, male cats have nipples. Yes, male cats can get infections or cancers of any tissue. That's... how "cells dividing to make more cells" works.
https://www.petco.com/content/content-hub/home/questions/00/1/123323.html
https://www.reddit.com/r/CATHELP/comments/1alkyru/what_is_this/
Yeah so Mr Teddy has a weird hard nipple but the other side is smaller and soft?
The nipple itself (not areola, surrounding skin, or under it) is hard and maybe a different color? Slightly shiny, about twice the size.
I feel like I should ask the vet, cuz that's what the articles I skimmed kept saying.
If you know what Grape Nuts are, the cereal, the bigger one is like that texture.
chat, how fucked is my mental health if the thought of my cat possibly having cancer is like "eh."
Not even "we'll ('just') get another" but a solid "huh. One fewer being to feel sad when I die."
No I don't feel good.
Yes the premenstrual farts do indicate the Bloodening is soon.
Of course I'm sure the rescheduled MH appt to Thursday is nothing to do with:
last Tuesday's breakdown
or my fucked-up sleep,
or bleaching my hair,
or getting tired and giving up on the green the same night.
Also a common side effect of Olanzapine is amenorrhea?!!?
Why THE FUCK wasn't that higher on the list JFC I don't care about the weight gain. Stop the useless waste of energy and (barely) oxygenated fluid. Kthxbai
Omg kthxbi
Lamotrigine helps half the ... it's not a month for me. It's a day or two over 3 weeks. Lucky. Fucking. Me.
Yes, IUSes apparently DO have a side effect of shortening your cycle.
YAAAAAAAY.
I was considering a copper IUD tbh, and was just going to put up with heavy, painful, exhausting, anaemic periods. But maaaaaybe the Olanzapine would even that out?
Nobody (yet) :
"Omg but maybe that means you're more 
🌸 Fertile 🪷 !!"
Fuck right off.
It's been 2 decades of my christing life wasting because of the IDEA that I might risk my life and long-term health to "fulfill my (body's) 'purpose' [sic: sick implications] "
Erm, also for various reasons, I am at higher chance of having twins, if we did go that route.
Which... Besides investing in earplugs, (no you are NOT a 'bad parent' for adapting your methods to your own gd needs)
is riskier for all involved, including my long-(my)-health-anxious af husbando.
Clarification: I am autistic and hearing is Very Good apparently. In my 30s, I still hear those bastardy cat and teenager screaming machines.
I wouldn't put in earplugs and leave them alone for hours. I'd 99% still hear them murmuring anyway, much less screaming. And/or noise monitor etc too.
I'd be fucking incensed if PMDD shit didn't go away for preggo-ness though.
JFC, really what would be the point? Cute small things to hug and keep alive, sure. And see grow up or learn things or whatever and steal them from school to come play with cats, but that's bullshit.
I would want a caesarian hysterectomy. I could NOT cope with period shit AND caring for 4 small things dependent on me for existence.
We have 2 indoor cats.
... If anyone has a good tip on easy to setup back garden cat enclosures / bird proof vegetable netting or whatever lmk. Ty
WHY DO I NEED TO KNOW ANY OF THIS SHIT ABOUT HORMONE LEVELS AND PHAMACOKINETIC INTERACTIONS IF
MY HUSBAND DIDN'T EVEN KNOW I BLEACH MY HAIR BEFORE DYEING IT GREEN.
WE ARE BOTH BRUNETTE.
Then fucking study it, you cunts.
... they *what*.
"As COCs are considered as a moderate inhibitor of CYP 1 A2,
when co-administered with
psychotropic drugs metabolized by CYP 1 A2
(duloxetine, clomipramine, imipramine, amitriptyline, olanzapine, clozapine, ziprasidone and mirtazapine),
COCs (and perhaps other HCs) may result in increased exposure to the psychotropic agents and potentially pose safety concerns [13]."
Ok right, what were mine again.
CYP2C19 normal metabolizer
CYP2D6 intermediate metabolizer
SLCO1B1 decreased function
CYP2C9 normal metabolizer
Uhhh w/e tf https://best.barnsleyccg.nhs.uk/media/s33jqsdx/anticonvulsants-for-mood-stabilisation.pdf Means as well. Idfk
"Doctor, doctor! I'm growing too many pyramids."
"Ah. Let's get you off something that causes Extrapyramidal Symptoms."
Olanzapine something something CYP 2 D6.
"Although olanzapine's metabolism includes the minor metabolic pathway of CYP2D6,
the presence of the CYP2D6 inhibitor fluoxetine does not have a clinically significant effect on olanzapine's clearance. [68]"
"Irritability associated with autism"?
What, you mean the social model of diability? Or the kyriarchy? I'm using that to mean "hierarchies in general".
"The main action of both first-generation and second-generation antipsychotics is thought to be
the post-synaptic blockade of D2 dopamine receptors.
All antipsychotics, with the exception of aripiprazole, are D2 antagonists.
Aripiprazole is a partial D2 agonist.
Aripiprazole binds to the D2 receptor with a high affinity similar to dopamine.
However, because it has low intrinsic activity,
it causes much lower activation of the receptor compared with dopamine."
I wish I knew more biochem or that my (Inital Response Team *only*) psychiatrist cared to.
"Aripiprazole is extensively metabolized in the liver by the
cytochrome P450 (CYP) superfamily of enzymes,
mainly CYP2D6 and CYP3A4.
Aripiprazole activity is thought to be primarily due to the parent drug, and to a lesser extent its major metabolite, dehydroaripiprazole.
The mean elimination half-life is approximately 75 hours for aripiprazole, but in individuals who have no appreciable CYP2D6 activity (poor metabolizers), the mean elimination half-life for aripiprazole is around 146 hours. (1)
The mean aripiprazole exposure for CYP2D6 poor and intermediate metabolizers is increased 1.5-fold compared with normal metabolizers (6)."
Oh hey look. Actualy disambiguation for once.
"CYP3A4 metabolizes 89% of quetiapine’s dose, and
the other 11% is metabolized mainly by CYP2D6 and other enzymes,
namely CYP3A5, CYP2C9 and CYP2C19 [1,6].
Eleven metabolites are known,
[...] can be divided into three different groups:
hydroxylated or sulfoxylated metabolites,
dealkylated metabolites and
a combination of the two reactions.
The reaction between CYP3A4 and quetiapine forms
N-desalkyl quetiapine, also known as norquetiapine,
which is further metabolized by CYP2D6 to form 7-hydroxy N-alkylated quetiapine.
CYP2D6 directly transforms quetiapine into 7-hydroxy quetiapine (Figure 1) [6,7].
All of these are active metabolites.
[...]
Furthermore, quetiapine is a
CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 inhibitor [1]. "
Again: fucking FINALLY.
"All the pharmacogenetic guidelines published to date were issued by
the DPWG, which recently published its recommendation on
the phenotype of CYP3A4 PM–quetiapine gene–drug interaction (Table 5).
CYP3A4 is, therefore, the only clinically relevant biomarker that can help individualize quetiapine pharmacotherapy based on the publication of pharmacogenetic guidelines.
Furthermore, the Clinical Pharmacogenetics Implementation Consortium (CPIC) rated
the drafting of a pharmacogenetic guideline on CYP2D6 and
antipsychotics (i.e., aripiprazole, brexpiprazole, pimozide, risperidone, iloperidone, perphenazine, clozapine, haloperidol, olanzapine, thioridazine, zuclopenthixol)
with a B level of priority [29]. "
The entire class just went OOOOOOOOOOOH!
"Apparently, this guideline will focus on the association of these drugs with CYP2D6 polymorphism.
This may be the reason why quetiapine is not included,
as the interaction between CYP2D6 and quetiapine exposure was previously considered irrelevant [30].
It would be expected that the CYP3A4–quetiapine interaction was included in the new CPIC guidelines."
Ok, so the first letter (before a number that both become their own thing or follow the gene supergroup) means the hormone that acts on that receptor?
Like D1 and D2 are dopamine, H1 is histamine, HT is fuck-knows, and M1 or M3 or M5 are "muscarinic"?
At least alpha-1 for adrenergic is easier to remember.
"It also acts on dopaminergic D1 and D2 receptors. Quetiapine is an antagonist for D2 receptors and 5-HT2 receptors.[10] "
[...]
"Furthermore, norquetiapine has an affinity for other receptors, such as H1 histamine receptor, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT7 serotonergic receptors, M1, M3, and M5 muscarinic receptors, and α1-adrenergic receptors.[12]"
https://www.mdpi.com/2673-9879/2/3/18
#BioChemistry #quÃmica #chem #chemistry #Biology #HumanBiology
I don't mean to be flip, but what's the upper limit on that anyway?
"There is an increased risk for suicidal thoughts and behavior associated with drug treatment in major depressive disorder patients."
Also muscarinic is for acetylcholine, btw. Uhhhh I know ATP is adenosine and the 3 fatty acids, cuz a chemistry teacher told us she'd know if we ever made a band by that name.
Acetylcholine has something to do with the Krebs cycle maybe...?
All of this skimmed research might actually mean something if I knew WHAT I was being treated for, under the assumption of, or how he is approaching it, ffs.
Is it mania? Depression? Biploar depression? Major unipolar depression? Schizophrenia maybe? IDFK.
Bastard said I was agitated in our first meeting (because he was talking over me, mid-fucking-answer and misinterpreting EVERY single thing I said, perhaps, maybe!)
Maybe it's for dementia? Who gd knows.
Or like, if he tested me for *anything at all* instead of going off (his) "clinical impressions".
(FROM OVER A YEAR AGO. On a day with 4 hours sleep. Without my dude to translate / be the [assumed!] penis-haver in the room so people listen to.. not me, but my words through his.)
But that would require documentation and explanations, I expect is the reason why not.
[ Was I going anywhere with this? ]
My friend just mentioned about another friend's ex being sorta well-known online. I was like "huh, okay".
Turns out they mega-rant every day.
Did not know I was becoming the "Monkey Looking Away" meme.
Anyway, I'll tell him I want to be a tree. Probably won't change anything but fuck it. It'll make me feel better.
What's the fursona version of -- FLORASONA. Florasona.
Or PerSeedling, I guess. Fungsona? Mycosona.
Kind of half-right I guess.
I wouldn't mind being a mangrove or something:
shoring up shallow coastlines, reducing erosion, slowing tsunamis.
Never quite a land or ocean or marsh plant but all and none of them.
Wait, Florsona flows better.
#FloraSona #Flowersona #Florsona #Plants #Plantsona #fursona #furries #scalies #barkies #xylem #phloem #photosyntheses #chitinies
My florsona is a mangrove, ye cunts.
https://lgbtqia.space/@MxVerda/112658564751349161
Oh hey. It's that thing where trans people draw the egg before cracking it.
Mx Verda (@[email protected])
Hey look, art: https://www.instagram.com/p/C8gXdgWqmeX/?igsh=eXp1NGZwdjN3ank3 Also I have a pillowfort #OortArtCloud #forest #fantasyArt #ent #mangrove #tree
I'm also proud of whatever the flying fuck this is:
https://lgbtqia.space/@MxVerda/113494725051484068
Yeah, nerds. Go browse #OortArtCloud if you're weird or even if you're not. Probably something in that that might inspire you to make art, go shower, walk to make kissy noises at animals (do not touch them, especially birds, thank you), or whatever your thing is.
#writing #writer #written #stories #story #idea #ideas #fiction #lit #literature