@notchoc That's their context in Noita. To translate them for a demake, we'd need to consider the new context.
Let's assume the demake is a gardening game, as andnull said. Still with simulated pixels of course, but most spells are about growing new pixels, not destroying them.
In Noita, enemies would attack you and each other, and sometimes destroy pixels too. So that would have to be flipped around as well: Sauvojen tuntija wouldn't have a matter-eating aura and explosive spells, it'd have a growing aura (or no aura, that's easier) and shoot seeds(?).
Many enemies (like Hämis) don't destroy terrain, just deplete HP. It's not obvious what the opposite of that could be. When they're aggressive, they make a demand of you: dodge or kill them, or they'll deplete a finite resource. If they're friendly and heal you (the literal opposite of damage), you just stand there and wait, no skill required.
The solution could be some kind of trade. They'll help you, but you have to help in return (an implicit demand).