Hilda Bastian

My latest update on nextgen Covid vaccines is a whopper, in part thanks to catching up with a new vax tracker:

- Clinical trial results for 2 vaxes

- 3 new clinical trials, incl a phase 2 intranasal vax trial in the US – and a pancoronavirus version of a vaccine that's already been rolled out

- 26 preclinical reports, with more showing prevention of transmission &/or durability

- a shelf-stable mucosal vax

Now @PLOS https://absolutelymaybe.plos.org/2025/11/06/a-bumper-update-on-next-generation-covid-vaccines-no-34/

#Covid #Covid19 #Vaccines

A Bumper Update on Next Generation Covid Vaccines (No 34) - Absolutely Maybe

This was always going to be a big month, with results from clinical trials of 2 vaccines, as well as 3 new…

Absolutely Maybe
Nov 6 at 10:47pmWeb
Show threadFediThing Nov 6

@hildabast @PLOS

Thank you once again 🙏

Interesting to see the Oxford vaccine repurposed as mucosal (if I understood correctly?), wonder if other injected vaccines might be reworked?

Hope we get something with long term protection from infection and/or long covid soon 🤞

Show threadHilda BastianNov 6

@FediThing @PLOS Thx! Not the first preclinical study for a mucosal version of the Oxford vax.

The question is who would pursue it. (There was a preclinical study of a mucosal version of the Moderna vax, too, but they invested elsewhere.) Hard to know who's tried, because often wouldn't be published.

Show thread0xDECAFBADNov 7
@hildabast @PLOS Too bad none of them will ever be approved in the US as long as worms for brains is in charge of HHS.
Show threadkaramazov1879Nov 7
@hildabast @PLOS Curious that covid is orange.
Show threadMuNov 7
@hildabast @PLOS soon I'm going to need to find out how to get these vaccines! I'd be willing to pay or travel!
Show threadFinal Round Player 😷🇪🇺🍸Nov 7

@hildabast @PLOS

What are the chances of a private vax in the UK that's more like the ~£15 of a private flu vax and not the current ~£100 for a private Covid vax?

While we wait for a cheap, pan-Rona, nasal vax that prevents infection.

Show threadMarjorieRNov 7
@jbond @hildabast @PLOS cell given the JVCI assume that the NHS can get one of the current COVID vaccines for £25 (I don't know what the NHS actually pay) then surely the NHS could let the rest of us have them at cost if they aren't prepared to vaccinate everyone for free?
Show threadHilda BastianNov 7
@jbond @PLOS I have no idea, sorry.
Show threadLittleGoatGirlNov 7
@hildabast @PLOS been waiting for these mucosal vaccines and not just for covid!
Show threadianNov 7
@hildabast @PLOS shot-phobic person very much looking forward to an intranasal option
Show threadSara-Jayne Slocombe (she/her)Nov 7

@hildabast THANK YOU SO MUCH for this!!!

I am so grateful that so many researchers out there realize that #CovidIsNotOver - and to you, for tracking it for us! This is wonderful!

Show threadpiper, aka vickaNov 14

@hildabast @PLOS

... i am having a hard time keeping track of which vaccine is which! looking for the bi- and trivalent subunit vaccine tried in mice and humans reported in nature from xiawei wei and colleagues at (i think) west china hospital

Nature Biomedical Engineeringnature biomedical engineering
https://doi.org/10.1038/s41551-025-01517-2

help a confused reader out? :)